Maximizing Ion Transmission in Differential Mobility Spectrometry

We provide modeling and experimental data describing the dominant ion-loss mechanisms for differential mobility spectrometry (DMS). Ion motion is considered from the inlet region of the mobility analyzer to the DMS exit, and losses resulting from diffusion to electrode surfaces, insufficient effecti...

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Bibliographic Details
Published in:Journal of the American Society for Mass Spectrometry 2017-10, Vol.28 (10), p.2151-2159
Main Authors: Schneider, Bradley B., Londry, Frank, Nazarov, Erkinjon G., Kang, Yang, Covey, Thomas R.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Bioinformatics
Biotechnology
Chemistry
Chemistry and Materials Science
Computer simulation
COMPUTERIZED SIMULATION
CONFIGURATION
DIFFUSION
ELECTRODES
FLOW RATE
Flow velocity
FLUID MECHANICS
FRAGMENTATION
Gas dynamics
GAS FLOW
INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
Ion motion
Mass spectrometry
MASS SPECTROSCOPY
MOBILITY
Organic Chemistry
Proteomics
REDUCTION
Research Article
Scientific imaging
Spectrometry
Spectroscopy
SURFACES
WAVE FORMS
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Summary:We provide modeling and experimental data describing the dominant ion-loss mechanisms for differential mobility spectrometry (DMS). Ion motion is considered from the inlet region of the mobility analyzer to the DMS exit, and losses resulting from diffusion to electrode surfaces, insufficient effective gap, ion fragmentation, and fringing field effects are considered for a commercial DMS system with 1-mm gap height. It is shown that losses due to diffusion and radial oscillations can be minimized with careful consideration of residence time, electrode spacing, gas flow rate, and waveform frequency. Fragmentation effects can be minimized by limitation of the separation field. When these parameters were optimized, fringing field effects at the DMS inlet contributed the most to signal reduction. We also describe a new DMS cell configuration that improves the gas dynamics at the mobility cell inlet. The new cell provides a gas jet that decreases the residence time for ions within the fringing field region, resulting in at least twofold increase in ion signal as determined by experimental data and simulations. Graphical Abstract ᅟ
ISSN:1044-0305
1879-1123
DOI:10.1007/s13361-017-1727-7