Synthesis and antitumor activity evaluation of different 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives

A new interesting family of 2,5-dialkyloxazolopyrano[3,2- c ]quinolinone derivatives 4a-l were synthesized in good yields using a convenient and successful method. Structures of all compounds were achieved by elemental analyses, IR, 1 H NMR, 13 C NMR, and mass techniques. The tetracyclic homologues...

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Bibliographic Details
Published in:Medicinal chemistry research 2019-01, Vol.28 (1), p.28-38
Main Authors: Hassanin, Hany M., Abd Elmoneam, Wafaa R., Mostafa, Mai A.
Format: Article
Language:English
Subjects:
5-Fluorouracil
60 APPLIED LIFE SCIENCES
Anticancer properties
Antitumor activity
Antitumor agents
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cancer
CARBON 13
Cell Biology
Cytotoxicity
Derivatives
FLUOROURACILS
Homology
HUMAN POPULATIONS
HYDROGEN 1
IN VITRO
Iridium
NEOPLASMS
NMR
NUCLEAR MAGNETIC RESONANCE
Original Research
Pharmacology/Toxicology
SYNTHESIS
TOXICITY
Tumor cell lines
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Summary:A new interesting family of 2,5-dialkyloxazolopyrano[3,2- c ]quinolinone derivatives 4a-l were synthesized in good yields using a convenient and successful method. Structures of all compounds were achieved by elemental analyses, IR, 1 H NMR, 13 C NMR, and mass techniques. The tetracyclic homologues 4a-l were evaluated for antitumor activity and cytotoxicity against a board of three human cancer cell lines (HepG-2, MCF-7, and HCT-116). The cells were treated with these compounds at differentiable dosages, and cell viability was determined. Significant anticancer activities were observed in vitro for some members of the series related to 5-fluorouracil and compounds 4c and 4f showed potent cytotoxic effect, that creates these compounds were disclosed as the most applicable anticancer agents against different cancer cell lines.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-018-2259-9