Dangerous and Cancer-Causing Properties of Products and Chemicals in the Oil Refining and Petrochemical Industry: Part I Carcinogenicity of Motor Fuels: Gasoline

• Published in: Toxicology and industrial health 1991-09, Vol.7 (5-6), p.143-152
• Main Author: Mehlman, Myron A.
• Format: Article
• Language: English
• Subjects: 02 PETROLEUM; 020600 - Petroleum- Health & Safety; 560300 - Chemicals Metabolism & Toxicology; ANIMALS; Benzene - adverse effects; Benzene Derivatives - adverse effects; BIOLOGICAL MODELS; Butadienes - adverse effects; CARCINOGENESIS; Carcinogens, Environmental - adverse effects; Chemical Industry; DISEASES; FUELS; GASOLINE; Gasoline - adverse effects; Humans; INDUSTRY; LIQUID FUELS; MAMMALS; MAN; Mutagens - adverse effects; NEOPLASMS; PATHOGENESIS; PETROLEUM INDUSTRY; PETROLEUM PRODUCTS; PRIMATES; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT; VERTEBRATES
• ISSN: 0748-2337; 1477-0393
• DOI: 10.1177/074823379100700516

Studies in humans and animals have shown that gasoline contains a number of cancer- causing and toxic chemicals such as 1,3-butadiene, benzene, toluene, ethylbenzene, xylenes, isoparaffins, methyltert-butylether, and others. The International Agency for Research on Cancer (IARC) in its Monograph Supplement 7 (1987) concludes that "in the absence of adequate data on humans, it is biologically plausible and prudent to re gard agents for which there is sufficient evidence of carcinogenicity in experimental animals as if they present a carcinogenic risk to humans." Epidemiological studies in humans provide important evidence of potential increased risk of leukemia, lymphatic tissue cancers, cancers of the brain, liver, and other organs and tissues. Recently (July, 1990) the American Conference of Governmental Industrial Hygiene (ACGIH) recom mended that the TLV-TWA for benzene be reduced from 1 ppm to 0.1 ppm (ACGIH, 1990). The Collegium Ramazzini and others have also recommended that the exposure level for 1,3-Butadiene be reduced from 1,000 ppm to below 0.2 ppm. This recom mendation is based on the findings that were presented at the Symposium on Toxicol ogy, Carcinogenesis, and Human Health Aspects of 1,3-Butadiene (Environ. Health Perspec., 1990). Thus, studies on health effects resulting from very low levels of ben zene, 1,3-butadiene, and other cancer-causing chemicals—components of gasoline— necessitate that all avoidable exposure to gasoline or gasoline vapors be avoided.