Absorption and retention of aluminum from drinking water: 1. Effect of citric and ascorbic acids on aluminum tissue levels in rabbits

Adult, male New Zealand rabbits (three per group) were administered drinking water containing aluminum chloride (0, 100, or 500 mg Al/liter) together with citrate (0.11 m), ascorbate (0.11 m), or no added ligand ad libitum for 12 weeks. They were fed ad libitum regular rabbit chow analyzed to contai...

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Bibliographic Details
Published in:Fundamental and applied toxicology 1990-05, Vol.14 (4), p.788-796
Main Authors: Fulton, Barbara, Jeffery, Elizabeth H.
Format: Article
Language:English
Subjects:
ABSORPTION
ALUMINIUM
Aluminum - administration & dosage
Aluminum - blood
Aluminum - pharmacokinetics
ANIMALS
ASCORBIC ACID
Ascorbic Acid - pharmacology
BIOLOGICAL EFFECTS
CARBOXYLIC ACID SALTS
CITRATES
Citrates - pharmacology
DISTRIBUTION
Dose-Response Relationship, Drug
DOSE-RESPONSE RELATIONSHIPS
Drinking
DRINKING WATER
ELEMENTS
HYDROGEN COMPOUNDS
Male
MAMMALS
METABOLISM
METALS
OXYGEN COMPOUNDS
POLLUTION
RABBITS
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
TISSUE DISTRIBUTION
VERTEBRATES
VITAMINS
Water
WATER 560300 > Chemicals Metabolism & Toxicology
WATER POLLUTION
Water Pollution, Chemical
Zinc - analysis
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Summary:Adult, male New Zealand rabbits (three per group) were administered drinking water containing aluminum chloride (0, 100, or 500 mg Al/liter) together with citrate (0.11 m), ascorbate (0.11 m), or no added ligand ad libitum for 12 weeks. They were fed ad libitum regular rabbit chow analyzed to contain 297 mg Al/kg. Treatment had no effect upon food and water intake or weight gain during the experimental period. No effect of aluminum was observed on tissue levels of the essential metals zinc, copper, and iron, or on hemoglobin and hematocrit values. Aluminum levels were found to increase in a dose-dependent manner in stomach and intestinal mucosa, kidney, bone, urine, and feces. There was only a slight accumulation in liver, and no accumulation in brain (cerebral cortex or hippocampus). Although plasma aluminum was directly related to aluminum intake, whole blood aluminum bore no relation to aluminum dose. Citrate had no effect on aluminum accumulation in the stomach or intestine, but significantly enhanced plasma and bone aluminum levesl. Ascorbate did not enhance aluminum accumulation in any tissue studied and even prevented accumulation in bone. Both citrate and ascorbate enhanced excretion of aluminum. Ascorbate therapy may be of potential clinical use to enhance aluminum excretion.
ISSN:0272-0590
1095-6832
DOI:10.1016/0272-0590(90)90303-2