Cholinergic Influence on Vestibular Stimulation-Induced Locus Coeruleus Inhibition in Rats

In our previous study, caloric stimulation (CS) of the vestibular apparatus inhibited noradrenergic neuronal activity in the locus coeruleus (LC) in urethane-anaesthetized rats. Therefore, the inhibition of LC noradrenergic neurons is involved in vestibulo-autonomic responses. Since motion sickness...

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Bibliographic Details
Published in:Acta oto-laryngologica 2000, Vol.120 (3), p.404-409
Main Author: Suetaka Nishiike, Noriaki Takeda, Atsuhiko Uno, Takeshi Kubo, Atsushi Yamatodani, Shoji Nakamura
Format: Article
Language:English
Subjects:
Animals
Aziridines - adverse effects
Biological and medical sciences
Caloric Tests - methods
Choline - adverse effects
Choline - analogs & derivatives
Cholinergic Fibers - drug effects
Disease Models, Animal
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Electrodes, Implanted
Locus Coeruleus - drug effects
Locus Coeruleus - physiopathology
Male
Medical sciences
Motion Sickness - chemically induced
Motion Sickness - drug therapy
Motion Sickness - physiopathology
Muscarinic Antagonists - pharmacology
Muscarinic Antagonists - therapeutic use
Neuromuscular Blocking Agents - adverse effects
Non tumoral diseases
Otorhinolaryngology. Stomatology
Rats
Rats, Sprague-Dawley
Scopolamine - pharmacology
Scopolamine - therapeutic use
Time Factors
Vestibule, Labyrinth - drug effects
Vestibule, Labyrinth - physiopathology
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Summary:In our previous study, caloric stimulation (CS) of the vestibular apparatus inhibited noradrenergic neuronal activity in the locus coeruleus (LC) in urethane-anaesthetized rats. Therefore, the inhibition of LC noradrenergic neurons is involved in vestibulo-autonomic responses. Since motion sickness can be cured by scopolamine, cholinergic neuron system may also be involved in vestibulo-autonomic responses. The present study examined the effects of intracerebroventricular injection of ethylcholine mustard aziridinium ion (AF64A), a presynaptic cholinergic neurotoxin, on CS-induced LC inhibition. In AF64A-treated rats, the CS-induced LC inhibition was less pronounced than in normal rats. In a subsequent series of experiments, the intravenous injection of scopolamine blocked the CS-induced LC inhibition. These findings suggest that central cholinergic neurons are associated with noradrenergic neuronal inhibition during the vestibulo-autonomic reflex.
ISSN:0001-6489
1651-2251
DOI:10.1080/000164800750000649