High Rate of Fatal Cases of Pediatric Septicemia Caused by Gram-Negative Bacteria with Extended-Spectrum Beta-Lactamases in Dar es Salaam, Tanzania

• Published in: Journal of Clinical Microbiology 2005-02, Vol.43 (2), p.745-749
• Main Authors: Blomberg, Bjørn, Jureen, Roland, Manji, Karim P, Tamim, Bushir S, Mwakagile, Davis S. M, Urassa, Willy K, Fataki, Maulidi, Msangi, Viola, Tellevik, Marit G, Maselle, Samwel Y, Langeland, Nina
• Format: Article
• Language: English
• Subjects: Bacteremia - microbiology; Bacteremia - mortality; Bacterial diseases; Bacterial sepsis; Bacteriology; beta-Lactamases - genetics; beta-Lactamases - metabolism; Biological and medical sciences; Child, Preschool; Enterobacteriaceae - enzymology; Enterobacteriaceae - pathogenicity; Enterobacteriaceae Infections - microbiology; Enterobacteriaceae Infections - mortality; Escherichia coli - enzymology; Escherichia coli - pathogenicity; Female; Fundamental and applied biological sciences. Psychology; Human bacterial diseases; Humans; Infant; Infant, Newborn; Infectious diseases; Klebsiella pneumoniae - enzymology; Klebsiella pneumoniae - pathogenicity; Male; Medical sciences; Microbiology; Salmonella enterica - classification; Salmonella enterica - enzymology; Salmonella enterica - pathogenicity; Tanzania - epidemiology
• ISSN: 0095-1137; 1098-660X
• DOI: 10.1128/JCM.43.2.745-749.2005

Extended-spectrumbeta-lactamases (ESBLs) were present in high proportions ofEscherichia coli (25% [9 of 36]) andKlebsiella pneumoniae isolates (17% [9 of52]) causing pediatric septicemia at a tertiary hospital inTanzania. Patients with septicemia due to ESBL-producing organisms hada significantly higher fatality rate than those with non-ESBL isolates(71% versus 39%, P = 0.039). This is thefirst report of the CTX-M-15 genotype of ESBLs on the African continentand the first observation of SHV-12 genotype in an isolate ofSalmonella enterica serotypeNewport.