Investigations into the C-deuteriation of aryl alkyl ketones using urea as a pro-base in the presence of a deuterium donor

Results are reported on the regioselective C‐deuteriation of a series of enolates derived from the deprotonation of aryl alkyl ketones using dilithiated urea as the pro‐base in the presence of a suitable deuterium donor. Copyright © 2006 John Wiley & Sons, Ltd.

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2006-06, Vol.49 (7), p.641-652
Main Authors: Coumbarides, Gregory S., Eames, Jason, Suggate, Michael J., Weerasooriya, Neluka
Format: Article
Language:English
Subjects:
alkyl aryl ketones
Chemistry
D-enols
deuterium
enolates and internal deuterium transfer
Exact sciences and technology
Organic chemistry
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Summary:Results are reported on the regioselective C‐deuteriation of a series of enolates derived from the deprotonation of aryl alkyl ketones using dilithiated urea as the pro‐base in the presence of a suitable deuterium donor. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.1083