Investigations into the C-deuteriation of aryl alkyl ketones using urea as a pro-base in the presence of a deuterium donor

Results are reported on the regioselective C‐deuteriation of a series of enolates derived from the deprotonation of aryl alkyl ketones using dilithiated urea as the pro‐base in the presence of a suitable deuterium donor. Copyright © 2006 John Wiley & Sons, Ltd.

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Published in:Journal of labelled compounds & radiopharmaceuticals 2006-06, Vol.49 (7), p.641-652
Main Authors: Coumbarides, Gregory S., Eames, Jason, Suggate, Michael J., Weerasooriya, Neluka
Format: Article
Language:English
Subjects:
alkyl aryl ketones
Chemistry
D-enols
deuterium
enolates and internal deuterium transfer
Exact sciences and technology
Organic chemistry
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container_end_page 652
container_issue 7
container_start_page 641
container_title Journal of labelled compounds & radiopharmaceuticals
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creator Coumbarides, Gregory S.
Eames, Jason
Suggate, Michael J.
Weerasooriya, Neluka
description Results are reported on the regioselective C‐deuteriation of a series of enolates derived from the deprotonation of aryl alkyl ketones using dilithiated urea as the pro‐base in the presence of a suitable deuterium donor. Copyright © 2006 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/jlcr.1083
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subjects alkyl aryl ketones
Chemistry
D-enols
deuterium
enolates and internal deuterium transfer
Exact sciences and technology
Organic chemistry
title Investigations into the C-deuteriation of aryl alkyl ketones using urea as a pro-base in the presence of a deuterium donor
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