Expression of rabbit C-reactive protein in transgenic mice inhibits development of antigen-induced arthritis

Objective: C-reactive protein (CRP) is a plasma protein of hepatic origin thought to play an important role in host defences. We used transgenic mice, capable of expressing high levels of rabbit CRP (serum concentration>50 µg mL) in response to dietary manipulation, to determine whether high leve...

Full description

Saved in:
Bibliographic Details
Published in:Scandinavian journal of rheumatology 2006-09, Vol.35 (5), p.351-355
Main Authors: Jiang, S., Xia, D., Samols, D.
Format: Article
Language:English
Subjects:
Acute-Phase Reaction - immunology
Acute-Phase Reaction - metabolism
Animals
Antigens - immunology
Arthritis, Experimental - genetics
Arthritis, Experimental - immunology
Arthritis, Experimental - metabolism
Biological and medical sciences
C-Reactive Protein - genetics
C-Reactive Protein - metabolism
Disease Models, Animal
Disease Progression
Diseases of the osteoarticular system
Female
Gene Expression Regulation - genetics
Interleukin-1beta - immunology
Medical sciences
Mice
Mice, Transgenic
Miscellaneous. Osteoarticular involvement in other diseases
Rabbits
Serum Albumin, Bovine - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: C-reactive protein (CRP) is a plasma protein of hepatic origin thought to play an important role in host defences. We used transgenic mice, capable of expressing high levels of rabbit CRP (serum concentration>50 µg mL) in response to dietary manipulation, to determine whether high levels of this acute-phase reactant can alter the course of experimentally induced monoarticular arthritis. Method: Arthritis was induced by a single injection of methylated bovine serum albumin (mBSA) on day 0 followed by injections of interleukin (IL)-1 . Results: In transgenic animals in which CRP expression had been suppressed (serum concentration50 µg mL on the day of mBSA and IL-1 injections, the inflammatory response was dramatically reduced at day 7. These mice manifested little to no evidence of joint inflammation. This anti-inflammatory effect of CRP was seen in animals with high CRP levels on days 0-1 following immunization and did not require elevated CRP levels during the period of rapid inflammatory progression, 4-7 days after challenge. Conclusion: CRP, expressed at the time of antigenic stimulation, effectively blocked the subsequent development of inflammatory arthritis in this model by altering the immune or inflammatory responses.
ISSN:0300-9742
1502-7732
DOI:10.1080/03009740600757963