Mixed Quantum-Classical Methods for Molecular Simulations of Biochemical Reactions With Microwave Fields: The Case Study of Myoglobin

Contradictory data in the huge literature on microwaves bio-effects may result from a poor understanding of the mechanisms of interaction between microwaves and biological systems. Molecular simulations of biochemical processes seem to be a promising tool to comprehend microwave induced bio-effects....

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Bibliographic Details
Published in:IEEE transactions on microwave theory and techniques 2008-11, Vol.56 (11), p.2511-2519
Main Authors: Apollonio, F., Liberti, M., Amadei, A., Aschi, M., Pellegrino, M., D'Alessandro, M., D'Abramo, M., Di Nola, A., d'Inzeo, G.
Format: Article
Language:English
Subjects:
Biochemistry
Bioelectromagnetics
Biological and medical sciences
Biological system modeling
Biological systems
Carbon monoxide
Cells (biology)
Chemistry
Covalence
Dynamics
Electromagnetic fields
Evolution
Fundamental and applied biological sciences. Psychology
In vivo
Microwave devices
Microwave theory and techniques
Microwaves
microwaves bio-effects
Miscellaneous
Molecular biophysics
molecular simulations
Myoglobin
Proteins
Radiation-biomolecule interaction
Radio frequency
Simulation
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Summary:Contradictory data in the huge literature on microwaves bio-effects may result from a poor understanding of the mechanisms of interaction between microwaves and biological systems. Molecular simulations of biochemical processes seem to be a promising tool to comprehend microwave induced bio-effects. Molecular simulations of classical and quantum events involved in relevant biochemical processes enable to follow the dynamic evolution of a biochemical reaction in the presence of microwave fields. In this paper, the action of a microwave signal (1 GHz) on the covalent binding process of a ligand (carbon monoxide) to a protein (myoglobin) has been studied. Our results indicate that microwave fields, with intensities much below the atomic/molecular electric interactions, cannot affect such biochemical process.
ISSN:0018-9480
1557-9670
DOI:10.1109/TMTT.2008.2005890