Simultaneous determination of ginsenoside (G-Re, G-Rg1, G-Rg2, G-F1, G-Rh1) and protopanaxatriol in human plasma and urine by LC–MS/MS and its application in a pharmacokinetics study of G-Re in volunteers

Ginsenoside Re (G-Re) improved the memory function of experimental animals in a preclinical study. Several types of saponins including G-Rg1, G-Rg2, G-F1, G-Rh1, and protopanaxatriol (PPT) may be the metabolites of G-Re according to reports from preclinical trials. In order to support a study of the...

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Bibliographic Details
Published in:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2011-07, Vol.879 (22), p.2011-2017
Main Authors: Liu, Lei, Huang, Jianquan, Hu, Xin, Li, Kexin, Sun, Chunhua
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chromatography, Liquid - methods
Drug Stability
Flow rate
formic acid
Fundamental and applied biological sciences. Psychology
General pharmacology
Ginsenoside Re
Ginsenosides - blood
Ginsenosides - metabolism
Ginsenosides - pharmacokinetics
Ginsenosides - urine
Human
Humans
laboratory animals
LC–MS/MS
Linear Models
liquid chromatography
Mathematical analysis
Medical sciences
memory
Metabolite
Metabolites
Pharmacokinetics
Pharmacology. Drug treatments
Reproducibility of Results
Sapogenins - blood
Sapogenins - metabolism
Sapogenins - pharmacokinetics
Sapogenins - urine
Saponins
Sensitivity and Specificity
Solid Phase Extraction
Solid phases
tandem mass spectrometry
Tandem Mass Spectrometry - methods
Urine
volunteers
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