Instrumental Activities of Daily Living Impairment Is Associated with Increased Amyloid Burden

Background/Aims: Instrumental activities of daily living (IADL) impairment in Alzheimer’s disease has been associated with global amyloid deposition in postmortem studies. We sought to determine whether IADL impairment is associated with increased cortical Pittsburgh Compound B (PiB) retention. Meth...

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Bibliographic Details
Published in:Dementia and geriatric cognitive disorders 2011-08, Vol.31 (6), p.443-450
Main Authors: Marshall, Gad A., Olson, Lauren E., Frey, Meghan T., Maye, Jacqueline, Becker, J. Alex, Rentz, Dorene M., Sperling, Reisa A., Johnson, Keith A.
Format: Article
Language:English
Subjects:
Activities of Daily Living - psychology
Aged
Aged, 80 and over
Alzheimer Disease - metabolism
Alzheimer Disease - psychology
Amyloid - metabolism
Amyloidosis - diagnostic imaging
Amyloidosis - metabolism
Analgesics
Aniline Compounds - metabolism
Biological and medical sciences
Body Burden
Data Interpretation, Statistical
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Neurology
Neuropharmacology
Neuropsychological Tests
Original
Original Research Article
Pharmacology. Drug treatments
Positron-Emission Tomography
Regression Analysis
Surveys and Questionnaires
Temporal Lobe - physiology
Thiazoles - metabolism
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Summary:Background/Aims: Instrumental activities of daily living (IADL) impairment in Alzheimer’s disease has been associated with global amyloid deposition in postmortem studies. We sought to determine whether IADL impairment is associated with increased cortical Pittsburgh Compound B (PiB) retention. Methods: Fifty-five subjects (19 normal older controls, NC, and 36 with mild cognitive impairment, MCI) underwent clinical assessments and dynamic PiB positron emission tomography imaging. Results: A linear multiple regression model showed that greater IADL impairment was associated with greater global PiB retention in all subjects (R 2 = 0.40; unstandardized partial regression coefficient, β = 5.8; p = 0.0002) and in MCI subjects only (R 2 = 0.28; β = 6.1; p = 0.003), but not in NC subjects only. Conclusion: These results suggest that daily functional impairment is related to greater amyloid burden in MCI.
ISSN:1420-8008
1421-9824
DOI:10.1159/000329543