The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats

Rats that consume high-energy (HE) diets (i.e., diets high in saturated fats and sugar) show impaired hippocampal-dependent learning and memory (e.g., Kanoski and Davidson (2011) [1]). To further investigate this effect, we trained rats given restricted access to low-fat lab chow on hippocampal-depe...

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Bibliographic Details
Published in:	Physiology & behavior 2012-08, Vol.107 (1), p.26-33
Main Authors:	Davidson, Terry L., Monnot, Andrew, Neal, Adelai U., Martin, Ashley A., Horton, J. Josiah, Zheng, Wei
Format:	Article
Language:	English
Subjects:	Acoustic Stimulation Adiposity Adiposity - physiology Analysis of Variance Animals Behavioral psychophysiology Biological and medical sciences blood-brain barrier Blood-Brain Barrier - physiopathology Body Weight - physiology Cognition Conditioning, Classical cortex Dietary Fats - adverse effects Discrimination, Psychological - physiology Disease Models, Animal Eating - physiology Energy balance Feeding Behavior - physiology Fundamental and applied biological sciences. Psychology high energy diet High-fat diet Hippocampus Hippocampus - physiology Learning Male Maze Learning - physiology Medical sciences memory Metabolic diseases Neuropsychological Tests Obesity Obesity - etiology Obesity - pathology Obesity - physiopathology Permeability Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley saturated fats sugars Time Factors
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