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Coadsorption effects in liquid—solid systems of the type silica—heptane + dioxane : III. Comparison of dioxane with ethyl acetate or 2-propanol as modifiers

The retention behaviour of several compound types (quinolines, nitroarenes, primary and secondary amines and phenols) was compared with dioxane (DX), ethyl acetate (EtOAc) and 2-propanol (iPrOH) as modifiers. As with tetrahydrofuran (THF), proton donor solutes were relatively more strongly retained...

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Bibliographic Details
Published in:Journal of Chromatography A 1987-06, Vol.395, p.489-494
Main Authors: Dzido, Tadeusz, Soczewiński, Edward
Format: Article
Language:English
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Summary:The retention behaviour of several compound types (quinolines, nitroarenes, primary and secondary amines and phenols) was compared with dioxane (DX), ethyl acetate (EtOAc) and 2-propanol (iPrOH) as modifiers. As with tetrahydrofuran (THF), proton donor solutes were relatively more strongly retained by DX than by EtOAc, which can be explained by their additional adsorption on the adsorbed DX molecules. For iPrOH as modifier, some dispersion of points in the log k′ DX vs. log k′ iPrOH correlation diagrams was observed: the points for phenols and anilines were grouped along individual correlation lines, but the points for the remaining solutes were dispersed. This can be explained by specific solvation effects of the associated alcohol molecules and by differences in solute/modifier competitive adsorption equilibria. For mixed modifiers (DX + THF), linear K′ vs. X DX plots were obtained, which can be utilized for “fine tuning” of selectivity.
ISSN:0021-9673
DOI:10.1016/S0021-9673(01)94136-6