The Role of Cholinergic Transmission in Outer Hair Cell Functioning Evaluated by Distortion Product Otoacoustic Emissions in Myasthenic Patients

Outer hair cells (OHCs) are the source of otoacoustic emissions, following a tropomyosin-miosin-dependent contraction, which are regulated by the olivocochlear bundle via the release of acetylcholine (ACh). ACh acts on ACh receptors (AChR) located on the OHC post-synaptic membrane. In myasthenia gra...

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Bibliographic Details
Published in:Acta oto-laryngologica 2001, Vol.121 (2), p.119-121
Main Author: Gaetano Paludetti, Walter Di Nardo, Aurelio D'Ecclesia, Amelia Evoli, Emanuele Scarano, Stefano Di Girolamo
Format: Article
Language:English
Subjects:
Acetylcholine - physiology
Acetylcholine Receptors Distortion Product Otoacoustic Emissions Electromotility Myasthenia Gravis Outer Hair Cells
Adult
Aged
Biological and medical sciences
Cholinergic Fibers - drug effects
Cholinergic Fibers - physiology
Diseases of striated muscles. Neuromuscular diseases
Female
Hair Cells, Auditory, Outer - drug effects
Hair Cells, Auditory, Outer - physiopathology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Myasthenia Gravis - diagnosis
Myasthenia Gravis - drug therapy
Myasthenia Gravis - physiopathology
Neurology
Otoacoustic Emissions, Spontaneous - drug effects
Otoacoustic Emissions, Spontaneous - physiology
Otorhinolaryngology functional investigation (larynx, voice, audiometry, vestibular function, equilibration...)
Pyridostigmine Bromide - therapeutic use
Reference Values
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
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Summary:Outer hair cells (OHCs) are the source of otoacoustic emissions, following a tropomyosin-miosin-dependent contraction, which are regulated by the olivocochlear bundle via the release of acetylcholine (ACh). ACh acts on ACh receptors (AChR) located on the OHC post-synaptic membrane. In myasthenia gravis (M.G.) neuromuscular transmission is reduced due to the action of AChR autoantibodies. It has previously been shown that M.G. induces a reduction in transient evoked otoacoustic emissions (TEOAEs), which is reversed after administration of a cholinesterase (AChE) inhibitor. Distortion product otoacoustic emissions (DPOAEs) were recorded before and 60 min after oral administration of 60 mg pyridostigmine bromide in 25 patients with normal hearing affected by M.G. The results were compared with those from 25 age-matched normal controls. Mean values of DPOAE amplitude in myasthenic patients were significantly (p
ISSN:0001-6489
1651-2251
DOI:10.1080/000164801300043127