Risk of cardiovascular disease and total mortality in adults with type 1 diabetes: Scottish registry linkage study

Randomized controlled trials have shown the importance of tight glucose control in type 1 diabetes (T1DM), but few recent studies have evaluated the risk of cardiovascular disease (CVD) and all-cause mortality among adults with T1DM. We evaluated these risks in adults with T1DM compared with the non...

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Bibliographic Details
Published in:PLoS medicine 2012-10, Vol.9 (10), p.e1001321-e1001321
Main Authors: Livingstone, Shona J, Looker, Helen C, Hothersall, Eleanor J, Wild, Sarah H, Lindsay, Robert S, Chalmers, John, Cleland, Stephen, Leese, Graham P, McKnight, John, Morris, Andrew D, Pearson, Donald W M, Peden, Norman R, Petrie, John R, Philip, Sam, Sattar, Naveed, Sullivan, Frank, Colhoun, Helen M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Child
Development and progression
Diabetes
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - mortality
Female
Humans
Insulin
Male
Medicine
Mortality
Physiological aspects
Prevalence studies (Epidemiology)
Registries - statistics & numerical data
Risk Factors
Scotland
Studies
Type 1 diabetes
United Kingdom
Young Adult
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Summary:Randomized controlled trials have shown the importance of tight glucose control in type 1 diabetes (T1DM), but few recent studies have evaluated the risk of cardiovascular disease (CVD) and all-cause mortality among adults with T1DM. We evaluated these risks in adults with T1DM compared with the non-diabetic population in a nationwide study from Scotland and examined control of CVD risk factors in those with T1DM. The Scottish Care Information-Diabetes Collaboration database was used to identify all people registered with T1DM and aged ≥20 years in 2005-2007 and to provide risk factor data. Major CVD events and deaths were obtained from the national hospital admissions database and death register. The age-adjusted incidence rate ratio (IRR) for CVD and mortality in T1DM (n = 21,789) versus the non-diabetic population (3.96 million) was estimated using Poisson regression. The age-adjusted IRR for first CVD event associated with T1DM versus the non-diabetic population was higher in women (3.0: 95% CI 2.4-3.8, p
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1001321