HIV-1 group M conserved elements vaccine

Many studies underscored the challenge of broadening CTL recognition through vaccination as they reflected typical HIV immunodominance profiles: the immune system focuses on relatively few immunodominant epitopes, leaving many epitopes subdominant or cryptic. Since subdominant responses may be criti...

Full description

Saved in:
Bibliographic Details
Published in:PLoS pathogens 2007-11, Vol.3 (11), p.e157-e157
Main Authors: Rolland, Morgane, Nickle, David C, Mullins, James I
Format: Article
Language:English
Subjects:
AIDS Vaccines - genetics
Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
Cytotoxicity
Design
HIV
HIV-1 - genetics
Homo (Human)
Human immunodeficiency virus
Humans
Immune system
Immunogenicity
Immunology
Immunotherapy, Active - methods
Infections
Lymphocytes
Multiculturalism & pluralism
Mutation
Opinions
Peptides
Proteins
Vaccines
Viral Proteins - genetics
Virology
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c729t-3713625bb653b49e5226def5ef4abbcc899b427992e8e2b497869c7029969a3d3
cites cdi_FETCH-LOGICAL-c729t-3713625bb653b49e5226def5ef4abbcc899b427992e8e2b497869c7029969a3d3
container_end_page e157
container_issue 11
container_start_page e157
container_title PLoS pathogens
container_volume 3
creator Rolland, Morgane
Nickle, David C
Mullins, James I
description Many studies underscored the challenge of broadening CTL recognition through vaccination as they reflected typical HIV immunodominance profiles: the immune system focuses on relatively few immunodominant epitopes, leaving many epitopes subdominant or cryptic. Since subdominant responses may be critical to effective suppression [37], mitigating immunodominance patterns could prove critical for successful vaccines.\n Additional epitopes were found to overlap CE/non-CE junctions (data not shown); thus extending CE immunogens could increase the number of peptides available to CD8+ T lymphocytes. [...]CE constructs have to be engineered optimally to elicit immune responses by capitalizing on the mechanisms governing epitope processing and presentation while preventing the creation of junctional immunogenicity or homology to the HIV or human proteome [52].
doi_str_mv 10.1371/journal.ppat.0030157
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1289031629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A202519183</galeid><doaj_id>oai_doaj_org_article_2d0d28428c2e4c089048c457408d5907</doaj_id><sourcerecordid>A202519183</sourcerecordid><originalsourceid>FETCH-LOGICAL-c729t-3713625bb653b49e5226def5ef4abbcc899b427992e8e2b497869c7029969a3d3</originalsourceid><addsrcrecordid>eNqVkl2L1TAQhoso7rr6D0QLguhFj8kkaZMbYVnUPbAq-HUb0nRae2ibmrQH_ffmeKpuZW8kFwmTZ96ZSd4keUjJhrKCvti52Q-m24yjmTaEMEJFcSs5pUKwrGAFv33tfJLcC2FHCKeM5neTEyqJAAHyNHl2uf2S0bTxbh7Tt6l1Q0C_xyrFDnscppDujbXtgPeTO7XpAj5Y9rPk8-tXny4us6v3b7YX51eZLUBNWeyM5SDKMhes5AoFQF5hLbDmpiytlUqVHAqlACVCJAqZK1sQUCpXhlXsLHl81B07F_QyZNAUpCKxeVCR2B6JypmdHn3bG_9DO9PqXwHnG2381NoONVSkAslBWkBuSZTg0nJRcCIroUgRtV4u1eayx8rGib3pVqLrm6H9qhu310CUlJRGgaeLgHffZgyT7ttgsevMgG4OOo8lCRAZwSf_gDfPtlCNie23Q-1iVXuQ1OdAQFBFJYvU5gYqrgr7Nn4h1m2MrxKerxIiM-H3qTFzCHr78cN_sO_WLD-y1rsQPNZ_Xo4SfXDp7yH1waV6cWlMe3T91f8mLbZkPwE7kt5m</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1289031629</pqid></control><display><type>article</type><title>HIV-1 group M conserved elements vaccine</title><source>PubMed (Medline)</source><source>ProQuest - Publicly Available Content Database</source><creator>Rolland, Morgane ; Nickle, David C ; Mullins, James I</creator><contributor>Manchester, Marianne</contributor><creatorcontrib>Rolland, Morgane ; Nickle, David C ; Mullins, James I ; Manchester, Marianne</creatorcontrib><description>Many studies underscored the challenge of broadening CTL recognition through vaccination as they reflected typical HIV immunodominance profiles: the immune system focuses on relatively few immunodominant epitopes, leaving many epitopes subdominant or cryptic. Since subdominant responses may be critical to effective suppression [37], mitigating immunodominance patterns could prove critical for successful vaccines.\n Additional epitopes were found to overlap CE/non-CE junctions (data not shown); thus extending CE immunogens could increase the number of peptides available to CD8+ T lymphocytes. [...]CE constructs have to be engineered optimally to elicit immune responses by capitalizing on the mechanisms governing epitope processing and presentation while preventing the creation of junctional immunogenicity or homology to the HIV or human proteome [52].</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.0030157</identifier><identifier>PMID: 18052528</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>AIDS Vaccines - genetics ; Amino Acid Sequence ; Animals ; Base Sequence ; Conserved Sequence ; Cytotoxicity ; Design ; HIV ; HIV-1 - genetics ; Homo (Human) ; Human immunodeficiency virus ; Humans ; Immune system ; Immunogenicity ; Immunology ; Immunotherapy, Active - methods ; Infections ; Lymphocytes ; Multiculturalism &amp; pluralism ; Mutation ; Opinions ; Peptides ; Proteins ; Vaccines ; Viral Proteins - genetics ; Virology ; Viruses</subject><ispartof>PLoS pathogens, 2007-11, Vol.3 (11), p.e157-e157</ispartof><rights>COPYRIGHT 2007 Public Library of Science</rights><rights>2007 Rolland et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Rolland M, Nickle DC, Mullins JI (2007) HIV-1 Group M Conserved Elements Vaccine. PLoS Pathog 3(11): e157. doi:10.1371/journal.ppat.0030157</rights><rights>2007 Rolland et al. 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c729t-3713625bb653b49e5226def5ef4abbcc899b427992e8e2b497869c7029969a3d3</citedby><cites>FETCH-LOGICAL-c729t-3713625bb653b49e5226def5ef4abbcc899b427992e8e2b497869c7029969a3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1289031629/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1289031629?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18052528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Manchester, Marianne</contributor><creatorcontrib>Rolland, Morgane</creatorcontrib><creatorcontrib>Nickle, David C</creatorcontrib><creatorcontrib>Mullins, James I</creatorcontrib><title>HIV-1 group M conserved elements vaccine</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>Many studies underscored the challenge of broadening CTL recognition through vaccination as they reflected typical HIV immunodominance profiles: the immune system focuses on relatively few immunodominant epitopes, leaving many epitopes subdominant or cryptic. Since subdominant responses may be critical to effective suppression [37], mitigating immunodominance patterns could prove critical for successful vaccines.\n Additional epitopes were found to overlap CE/non-CE junctions (data not shown); thus extending CE immunogens could increase the number of peptides available to CD8+ T lymphocytes. [...]CE constructs have to be engineered optimally to elicit immune responses by capitalizing on the mechanisms governing epitope processing and presentation while preventing the creation of junctional immunogenicity or homology to the HIV or human proteome [52].</description><subject>AIDS Vaccines - genetics</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Conserved Sequence</subject><subject>Cytotoxicity</subject><subject>Design</subject><subject>HIV</subject><subject>HIV-1 - genetics</subject><subject>Homo (Human)</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunogenicity</subject><subject>Immunology</subject><subject>Immunotherapy, Active - methods</subject><subject>Infections</subject><subject>Lymphocytes</subject><subject>Multiculturalism &amp; pluralism</subject><subject>Mutation</subject><subject>Opinions</subject><subject>Peptides</subject><subject>Proteins</subject><subject>Vaccines</subject><subject>Viral Proteins - genetics</subject><subject>Virology</subject><subject>Viruses</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqVkl2L1TAQhoso7rr6D0QLguhFj8kkaZMbYVnUPbAq-HUb0nRae2ibmrQH_ffmeKpuZW8kFwmTZ96ZSd4keUjJhrKCvti52Q-m24yjmTaEMEJFcSs5pUKwrGAFv33tfJLcC2FHCKeM5neTEyqJAAHyNHl2uf2S0bTxbh7Tt6l1Q0C_xyrFDnscppDujbXtgPeTO7XpAj5Y9rPk8-tXny4us6v3b7YX51eZLUBNWeyM5SDKMhes5AoFQF5hLbDmpiytlUqVHAqlACVCJAqZK1sQUCpXhlXsLHl81B07F_QyZNAUpCKxeVCR2B6JypmdHn3bG_9DO9PqXwHnG2381NoONVSkAslBWkBuSZTg0nJRcCIroUgRtV4u1eayx8rGib3pVqLrm6H9qhu310CUlJRGgaeLgHffZgyT7ttgsevMgG4OOo8lCRAZwSf_gDfPtlCNie23Q-1iVXuQ1OdAQFBFJYvU5gYqrgr7Nn4h1m2MrxKerxIiM-H3qTFzCHr78cN_sO_WLD-y1rsQPNZ_Xo4SfXDp7yH1waV6cWlMe3T91f8mLbZkPwE7kt5m</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Rolland, Morgane</creator><creator>Nickle, David C</creator><creator>Mullins, James I</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20071101</creationdate><title>HIV-1 group M conserved elements vaccine</title><author>Rolland, Morgane ; Nickle, David C ; Mullins, James I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c729t-3713625bb653b49e5226def5ef4abbcc899b427992e8e2b497869c7029969a3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>AIDS Vaccines - genetics</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Conserved Sequence</topic><topic>Cytotoxicity</topic><topic>Design</topic><topic>HIV</topic><topic>HIV-1 - genetics</topic><topic>Homo (Human)</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunogenicity</topic><topic>Immunology</topic><topic>Immunotherapy, Active - methods</topic><topic>Infections</topic><topic>Lymphocytes</topic><topic>Multiculturalism &amp; pluralism</topic><topic>Mutation</topic><topic>Opinions</topic><topic>Peptides</topic><topic>Proteins</topic><topic>Vaccines</topic><topic>Viral Proteins - genetics</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rolland, Morgane</creatorcontrib><creatorcontrib>Nickle, David C</creatorcontrib><creatorcontrib>Mullins, James I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest_Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rolland, Morgane</au><au>Nickle, David C</au><au>Mullins, James I</au><au>Manchester, Marianne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV-1 group M conserved elements vaccine</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>3</volume><issue>11</issue><spage>e157</spage><epage>e157</epage><pages>e157-e157</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>Many studies underscored the challenge of broadening CTL recognition through vaccination as they reflected typical HIV immunodominance profiles: the immune system focuses on relatively few immunodominant epitopes, leaving many epitopes subdominant or cryptic. Since subdominant responses may be critical to effective suppression [37], mitigating immunodominance patterns could prove critical for successful vaccines.\n Additional epitopes were found to overlap CE/non-CE junctions (data not shown); thus extending CE immunogens could increase the number of peptides available to CD8+ T lymphocytes. [...]CE constructs have to be engineered optimally to elicit immune responses by capitalizing on the mechanisms governing epitope processing and presentation while preventing the creation of junctional immunogenicity or homology to the HIV or human proteome [52].</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>18052528</pmid><doi>10.1371/journal.ppat.0030157</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1553-7374
ispartof PLoS pathogens, 2007-11, Vol.3 (11), p.e157-e157
issn 1553-7374
1553-7366
1553-7374
language eng
recordid cdi_plos_journals_1289031629
source PubMed (Medline); ProQuest - Publicly Available Content Database
subjects AIDS Vaccines - genetics
Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
Cytotoxicity
Design
HIV
HIV-1 - genetics
Homo (Human)
Human immunodeficiency virus
Humans
Immune system
Immunogenicity
Immunology
Immunotherapy, Active - methods
Infections
Lymphocytes
Multiculturalism & pluralism
Mutation
Opinions
Peptides
Proteins
Vaccines
Viral Proteins - genetics
Virology
Viruses
title HIV-1 group M conserved elements vaccine
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T09%3A58%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HIV-1%20group%20M%20conserved%20elements%20vaccine&rft.jtitle=PLoS%20pathogens&rft.au=Rolland,%20Morgane&rft.date=2007-11-01&rft.volume=3&rft.issue=11&rft.spage=e157&rft.epage=e157&rft.pages=e157-e157&rft.issn=1553-7374&rft.eissn=1553-7374&rft_id=info:doi/10.1371/journal.ppat.0030157&rft_dat=%3Cgale_plos_%3EA202519183%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c729t-3713625bb653b49e5226def5ef4abbcc899b427992e8e2b497869c7029969a3d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1289031629&rft_id=info:pmid/18052528&rft_galeid=A202519183&rfr_iscdi=true