The next opportunity in anti-malaria drug discovery: the liver stage

Almost all of these efforts have focused on the cyclic blood stage of the disease, partly because the parasites can be easily maintained in culture through addition of human red blood cells to the growth medium, and partly because blood stage infection causes malaria's characteristic symptoms....

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Bibliographic Details
Published in:PLoS pathogens 2011-09, Vol.7 (9), p.e1002178-e1002178
Main Authors: Derbyshire, Emily R, Mota, Maria M, Clardy, Jon
Format: Article
Language:English
Subjects:
Antimalarials - therapeutic use
Artemisinins - therapeutic use
Chemistry
Chloroquine - therapeutic use
Drug Discovery
Drug Resistance, Microbial
Humans
Liver - parasitology
Malaria
Malaria - drug therapy
Medicine
Mosquitoes
Opinion
Parasites
Plasmodium malariae - drug effects
Plasmodium malariae - physiology
Proteins
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Summary:Almost all of these efforts have focused on the cyclic blood stage of the disease, partly because the parasites can be easily maintained in culture through addition of human red blood cells to the growth medium, and partly because blood stage infection causes malaria's characteristic symptoms. During their obligatory blood meals, infected female mosquitoes transmit protozoan parasites belonging to the genus Plasmodium, and their proliferation in the human host causes malaria's symptoms (Figure 1).
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1002178