Egyptian H5N1 influenza viruses-cause for concern?

[...]both studies, and findings by others [16]-[18], suggest that a shift towards human-type receptor-binding specificity may be necessary, but not sufficient, for H5N1 virus transmissibility in mammals. In the Herfst and Imai studies, loss of this glycosylation site occurred during the first virus...

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Bibliographic Details
Published in:PLoS pathogens 2012-11, Vol.8 (11), p.e1002932-e1002932
Main Authors: Neumann, Gabriele, Macken, Catherine A, Karasin, Alexander I, Fouchier, Ron A M, Kawaoka, Yoshihiro
Format: Article
Language:English
Subjects:
Animals
Avian flu
BASIC BIOLOGICAL SCIENCES
Biology
Birds
Birds - virology
Disease transmission
Egypt
Health aspects
Host-parasite relationships
Humans
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza in Birds - epidemiology
Influenza in Birds - transmission
Influenza in Birds - virology
Influenza viruses
Influenza, Human - epidemiology
Influenza, Human - transmission
Influenza, Human - virology
Mutation
Opinion
Pandemics
Pharmaceuticals
Phylogenetics
Studies
Virus research
Viruses
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Summary:[...]both studies, and findings by others [16]-[18], suggest that a shift towards human-type receptor-binding specificity may be necessary, but not sufficient, for H5N1 virus transmissibility in mammals. In the Herfst and Imai studies, loss of this glycosylation site occurred during the first virus passages in ferrets, suggesting that this trait is essential for H5 virus transmissibility in ferrets. Since lack of the HA154-156 glycosylation site appears to be critical for H5 virus transmission in mammals, we inspected avian H5N1 viruses for this feature.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1002932