Transmission in heteronymous spinal pathways is modified after stroke and related to motor incoordination

Changes in reflex spinal pathways after stroke have been shown to affect motor activity in agonist and antagonist muscles acting at the same joint. However, only a few studies have evaluated the heteronymous reflex pathways modulating motoneuronal activity at different joints. This study investigate...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2009-01, Vol.4 (1), p.e4123-e4123
Main Authors: Dyer, Joseph-Omer, Maupas, Eric, de Andrade Melo, Sibele, Bourbonnais, Daniel, Fleury, Jean, Forget, Robert
Format: Article
Language:English
Subjects:
Adult
Aged
Ankle
Ataxia - etiology
Ataxia - physiopathology
Case-Control Studies
Coordination
Female
Femoral Nerve - physiopathology
Femur
Humans
Inhibition
Knee
Leg - innervation
Leg - physiopathology
Legs
Male
Middle Aged
Motor activity
Motor Neurons - physiology
Muscle Spasticity - etiology
Muscle Spasticity - physiopathology
Muscle, Skeletal - innervation
Muscle, Skeletal - physiopathology
Muscles
Neural Pathways - physiopathology
Neurological Disorders/Cerebrovascular Disease
Neuroscience/Motor Systems
Neuroscience/Neuronal Signaling Mechanisms
Paresis - etiology
Paresis - physiopathology
Pathways
Quadriceps muscle
Recovery
Recovery of Function - physiology
Reflex - physiology
Rodents
Spasticity
Stroke
Stroke - complications
Stroke - physiopathology
Tibial Nerve - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c759t-98be352d04df4a9d1c932bafee9006c62afa0042a3e30d40e57d4adc13ea6e193
cites cdi_FETCH-LOGICAL-c759t-98be352d04df4a9d1c932bafee9006c62afa0042a3e30d40e57d4adc13ea6e193
container_end_page e4123
container_issue 1
container_start_page e4123
container_title PloS one
container_volume 4
creator Dyer, Joseph-Omer
Maupas, Eric
de Andrade Melo, Sibele
Bourbonnais, Daniel
Fleury, Jean
Forget, Robert
description Changes in reflex spinal pathways after stroke have been shown to affect motor activity in agonist and antagonist muscles acting at the same joint. However, only a few studies have evaluated the heteronymous reflex pathways modulating motoneuronal activity at different joints. This study investigates whether there are changes in the spinal facilitatory and inhibitory pathways linking knee to ankle extensors and if such changes may be related to motor deficits after stroke. The early facilitation and later inhibition of soleus H reflex evoked by the stimulation of femoral nerve at 2 times the motor threshold of the quadriceps were assessed in 15 healthy participants and on the paretic and the non-paretic sides of 15 stroke participants. The relationships between this reflex modulation and the levels of motor recovery, coordination and spasticity were then studied. Results show a significant (Mann-Whitney U; P
doi_str_mv 10.1371/journal.pone.0004123
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1289573086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A473426270</galeid><doaj_id>oai_doaj_org_article_d651d2a6661a4c528f4b5e08f34d145d</doaj_id><sourcerecordid>A473426270</sourcerecordid><originalsourceid>FETCH-LOGICAL-c759t-98be352d04df4a9d1c932bafee9006c62afa0042a3e30d40e57d4adc13ea6e193</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rr6D0QLwoIXM-araXsjLIsfAwsLunobzjSnM1nbZkxSdf69Z5yqMyIouUhInvMm7zk5WfaYszmXJX9x68cwQDff-AHnjDHFhbyTnfJaipkWTN49WJ9kD2K8ZayQldb3sxNecyEqrk8zdxNgiL2L0fkhd0O-xoTBD9vejzGPG0dX5BtI66-wjbmLee-tax3aHFoC85iC_4Q5DDYP2EGig-QJSj6QWuN9sCSRSPxhdq-FLuKjaT7LPrx-dXP5dnZ1_WZxeXE1a8qiTrO6WqIshGXKtgpqyxsysYQWsWZMN1pAC2RWgETJrGJYlFaBbbhE0EiOz7Kne91N56OZshQNF1VdlJJVmojFnrAebs0muB7C1nhw5seGDysDIbmmQ2N1wa0ArTUH1RSiatWyQFa1UlmuCktaL6fbxmWPtsEhBeiORI9PBrc2K__FCM1KxjkJnE8CwX8eMSZDxWiw62BAKoHRumJUweKfoGCiLAVjBD77A_x7EuZ7agXk0w2tp-c1NCz2rqE_1Trav1ClVEKLcif7_CiAmITf0grGGM3i_bv_Z68_HrPnB-waoUvr6Ltx92fiMaj2YBN8jAHbX1nmzOxa4qdPs2sJM7UEhT05rNDvoKkH5Hd0aAk8</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1289573086</pqid></control><display><type>article</type><title>Transmission in heteronymous spinal pathways is modified after stroke and related to motor incoordination</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><creator>Dyer, Joseph-Omer ; Maupas, Eric ; de Andrade Melo, Sibele ; Bourbonnais, Daniel ; Fleury, Jean ; Forget, Robert</creator><contributor>Hochman, Shawn</contributor><creatorcontrib>Dyer, Joseph-Omer ; Maupas, Eric ; de Andrade Melo, Sibele ; Bourbonnais, Daniel ; Fleury, Jean ; Forget, Robert ; Hochman, Shawn</creatorcontrib><description>Changes in reflex spinal pathways after stroke have been shown to affect motor activity in agonist and antagonist muscles acting at the same joint. However, only a few studies have evaluated the heteronymous reflex pathways modulating motoneuronal activity at different joints. This study investigates whether there are changes in the spinal facilitatory and inhibitory pathways linking knee to ankle extensors and if such changes may be related to motor deficits after stroke. The early facilitation and later inhibition of soleus H reflex evoked by the stimulation of femoral nerve at 2 times the motor threshold of the quadriceps were assessed in 15 healthy participants and on the paretic and the non-paretic sides of 15 stroke participants. The relationships between this reflex modulation and the levels of motor recovery, coordination and spasticity were then studied. Results show a significant (Mann-Whitney U; P&lt;0.05) increase in both the peak amplitude (mean+/-SEM: 80+/-22% enhancement of the control H reflex) and duration (4.2+/-0.5 ms) of the facilitation on the paretic side of the stroke individuals compared to their non-paretic side (36+/-6% and 2.9+/-0.4 ms) and to the values of the control subjects (33+/-4% and 2.8+/-0.4 ms, respectively). Moreover, the later strong inhibition observed in all control subjects was decreased in the stroke subjects. Both the peak amplitude and the duration of the increased facilitation were inversely correlated (Spearman r = -0.65; P = 0.009 and r = -0.67; P = 0.007, respectively) with the level of coordination (LEMOCOT) of the paretic leg. Duration of this facilitation was also correlated (r = -0.58, P = 0.024) with the level of motor recovery (CMSA). These results confirm changes in transmission in heteronymous spinal pathways that are related to motor deficits after stroke.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0004123</identifier><identifier>PMID: 19122816</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Ankle ; Ataxia - etiology ; Ataxia - physiopathology ; Case-Control Studies ; Coordination ; Female ; Femoral Nerve - physiopathology ; Femur ; Humans ; Inhibition ; Knee ; Leg - innervation ; Leg - physiopathology ; Legs ; Male ; Middle Aged ; Motor activity ; Motor Neurons - physiology ; Muscle Spasticity - etiology ; Muscle Spasticity - physiopathology ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiopathology ; Muscles ; Neural Pathways - physiopathology ; Neurological Disorders/Cerebrovascular Disease ; Neuroscience/Motor Systems ; Neuroscience/Neuronal Signaling Mechanisms ; Paresis - etiology ; Paresis - physiopathology ; Pathways ; Quadriceps muscle ; Recovery ; Recovery of Function - physiology ; Reflex - physiology ; Rodents ; Spasticity ; Stroke ; Stroke - complications ; Stroke - physiopathology ; Tibial Nerve - physiopathology</subject><ispartof>PloS one, 2009-01, Vol.4 (1), p.e4123-e4123</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Dyer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Dyer et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c759t-98be352d04df4a9d1c932bafee9006c62afa0042a3e30d40e57d4adc13ea6e193</citedby><cites>FETCH-LOGICAL-c759t-98be352d04df4a9d1c932bafee9006c62afa0042a3e30d40e57d4adc13ea6e193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1289573086/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1289573086?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25751,27922,27923,37010,37011,44588,53789,53791,74896</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19122816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hochman, Shawn</contributor><creatorcontrib>Dyer, Joseph-Omer</creatorcontrib><creatorcontrib>Maupas, Eric</creatorcontrib><creatorcontrib>de Andrade Melo, Sibele</creatorcontrib><creatorcontrib>Bourbonnais, Daniel</creatorcontrib><creatorcontrib>Fleury, Jean</creatorcontrib><creatorcontrib>Forget, Robert</creatorcontrib><title>Transmission in heteronymous spinal pathways is modified after stroke and related to motor incoordination</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Changes in reflex spinal pathways after stroke have been shown to affect motor activity in agonist and antagonist muscles acting at the same joint. However, only a few studies have evaluated the heteronymous reflex pathways modulating motoneuronal activity at different joints. This study investigates whether there are changes in the spinal facilitatory and inhibitory pathways linking knee to ankle extensors and if such changes may be related to motor deficits after stroke. The early facilitation and later inhibition of soleus H reflex evoked by the stimulation of femoral nerve at 2 times the motor threshold of the quadriceps were assessed in 15 healthy participants and on the paretic and the non-paretic sides of 15 stroke participants. The relationships between this reflex modulation and the levels of motor recovery, coordination and spasticity were then studied. Results show a significant (Mann-Whitney U; P&lt;0.05) increase in both the peak amplitude (mean+/-SEM: 80+/-22% enhancement of the control H reflex) and duration (4.2+/-0.5 ms) of the facilitation on the paretic side of the stroke individuals compared to their non-paretic side (36+/-6% and 2.9+/-0.4 ms) and to the values of the control subjects (33+/-4% and 2.8+/-0.4 ms, respectively). Moreover, the later strong inhibition observed in all control subjects was decreased in the stroke subjects. Both the peak amplitude and the duration of the increased facilitation were inversely correlated (Spearman r = -0.65; P = 0.009 and r = -0.67; P = 0.007, respectively) with the level of coordination (LEMOCOT) of the paretic leg. Duration of this facilitation was also correlated (r = -0.58, P = 0.024) with the level of motor recovery (CMSA). These results confirm changes in transmission in heteronymous spinal pathways that are related to motor deficits after stroke.</description><subject>Adult</subject><subject>Aged</subject><subject>Ankle</subject><subject>Ataxia - etiology</subject><subject>Ataxia - physiopathology</subject><subject>Case-Control Studies</subject><subject>Coordination</subject><subject>Female</subject><subject>Femoral Nerve - physiopathology</subject><subject>Femur</subject><subject>Humans</subject><subject>Inhibition</subject><subject>Knee</subject><subject>Leg - innervation</subject><subject>Leg - physiopathology</subject><subject>Legs</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor activity</subject><subject>Motor Neurons - physiology</subject><subject>Muscle Spasticity - etiology</subject><subject>Muscle Spasticity - physiopathology</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscles</subject><subject>Neural Pathways - physiopathology</subject><subject>Neurological Disorders/Cerebrovascular Disease</subject><subject>Neuroscience/Motor Systems</subject><subject>Neuroscience/Neuronal Signaling Mechanisms</subject><subject>Paresis - etiology</subject><subject>Paresis - physiopathology</subject><subject>Pathways</subject><subject>Quadriceps muscle</subject><subject>Recovery</subject><subject>Recovery of Function - physiology</subject><subject>Reflex - physiology</subject><subject>Rodents</subject><subject>Spasticity</subject><subject>Stroke</subject><subject>Stroke - complications</subject><subject>Stroke - physiopathology</subject><subject>Tibial Nerve - physiopathology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLwoIXM-araXsjLIsfAwsLunobzjSnM1nbZkxSdf69Z5yqMyIouUhInvMm7zk5WfaYszmXJX9x68cwQDff-AHnjDHFhbyTnfJaipkWTN49WJ9kD2K8ZayQldb3sxNecyEqrk8zdxNgiL2L0fkhd0O-xoTBD9vejzGPG0dX5BtI66-wjbmLee-tax3aHFoC85iC_4Q5DDYP2EGig-QJSj6QWuN9sCSRSPxhdq-FLuKjaT7LPrx-dXP5dnZ1_WZxeXE1a8qiTrO6WqIshGXKtgpqyxsysYQWsWZMN1pAC2RWgETJrGJYlFaBbbhE0EiOz7Kne91N56OZshQNF1VdlJJVmojFnrAebs0muB7C1nhw5seGDysDIbmmQ2N1wa0ArTUH1RSiatWyQFa1UlmuCktaL6fbxmWPtsEhBeiORI9PBrc2K__FCM1KxjkJnE8CwX8eMSZDxWiw62BAKoHRumJUweKfoGCiLAVjBD77A_x7EuZ7agXk0w2tp-c1NCz2rqE_1Trav1ClVEKLcif7_CiAmITf0grGGM3i_bv_Z68_HrPnB-waoUvr6Ltx92fiMaj2YBN8jAHbX1nmzOxa4qdPs2sJM7UEhT05rNDvoKkH5Hd0aAk8</recordid><startdate>20090105</startdate><enddate>20090105</enddate><creator>Dyer, Joseph-Omer</creator><creator>Maupas, Eric</creator><creator>de Andrade Melo, Sibele</creator><creator>Bourbonnais, Daniel</creator><creator>Fleury, Jean</creator><creator>Forget, Robert</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20090105</creationdate><title>Transmission in heteronymous spinal pathways is modified after stroke and related to motor incoordination</title><author>Dyer, Joseph-Omer ; Maupas, Eric ; de Andrade Melo, Sibele ; Bourbonnais, Daniel ; Fleury, Jean ; Forget, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c759t-98be352d04df4a9d1c932bafee9006c62afa0042a3e30d40e57d4adc13ea6e193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Ankle</topic><topic>Ataxia - etiology</topic><topic>Ataxia - physiopathology</topic><topic>Case-Control Studies</topic><topic>Coordination</topic><topic>Female</topic><topic>Femoral Nerve - physiopathology</topic><topic>Femur</topic><topic>Humans</topic><topic>Inhibition</topic><topic>Knee</topic><topic>Leg - innervation</topic><topic>Leg - physiopathology</topic><topic>Legs</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor activity</topic><topic>Motor Neurons - physiology</topic><topic>Muscle Spasticity - etiology</topic><topic>Muscle Spasticity - physiopathology</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscles</topic><topic>Neural Pathways - physiopathology</topic><topic>Neurological Disorders/Cerebrovascular Disease</topic><topic>Neuroscience/Motor Systems</topic><topic>Neuroscience/Neuronal Signaling Mechanisms</topic><topic>Paresis - etiology</topic><topic>Paresis - physiopathology</topic><topic>Pathways</topic><topic>Quadriceps muscle</topic><topic>Recovery</topic><topic>Recovery of Function - physiology</topic><topic>Reflex - physiology</topic><topic>Rodents</topic><topic>Spasticity</topic><topic>Stroke</topic><topic>Stroke - complications</topic><topic>Stroke - physiopathology</topic><topic>Tibial Nerve - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dyer, Joseph-Omer</creatorcontrib><creatorcontrib>Maupas, Eric</creatorcontrib><creatorcontrib>de Andrade Melo, Sibele</creatorcontrib><creatorcontrib>Bourbonnais, Daniel</creatorcontrib><creatorcontrib>Fleury, Jean</creatorcontrib><creatorcontrib>Forget, Robert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (ProQuest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dyer, Joseph-Omer</au><au>Maupas, Eric</au><au>de Andrade Melo, Sibele</au><au>Bourbonnais, Daniel</au><au>Fleury, Jean</au><au>Forget, Robert</au><au>Hochman, Shawn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission in heteronymous spinal pathways is modified after stroke and related to motor incoordination</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2009-01-05</date><risdate>2009</risdate><volume>4</volume><issue>1</issue><spage>e4123</spage><epage>e4123</epage><pages>e4123-e4123</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Changes in reflex spinal pathways after stroke have been shown to affect motor activity in agonist and antagonist muscles acting at the same joint. However, only a few studies have evaluated the heteronymous reflex pathways modulating motoneuronal activity at different joints. This study investigates whether there are changes in the spinal facilitatory and inhibitory pathways linking knee to ankle extensors and if such changes may be related to motor deficits after stroke. The early facilitation and later inhibition of soleus H reflex evoked by the stimulation of femoral nerve at 2 times the motor threshold of the quadriceps were assessed in 15 healthy participants and on the paretic and the non-paretic sides of 15 stroke participants. The relationships between this reflex modulation and the levels of motor recovery, coordination and spasticity were then studied. Results show a significant (Mann-Whitney U; P&lt;0.05) increase in both the peak amplitude (mean+/-SEM: 80+/-22% enhancement of the control H reflex) and duration (4.2+/-0.5 ms) of the facilitation on the paretic side of the stroke individuals compared to their non-paretic side (36+/-6% and 2.9+/-0.4 ms) and to the values of the control subjects (33+/-4% and 2.8+/-0.4 ms, respectively). Moreover, the later strong inhibition observed in all control subjects was decreased in the stroke subjects. Both the peak amplitude and the duration of the increased facilitation were inversely correlated (Spearman r = -0.65; P = 0.009 and r = -0.67; P = 0.007, respectively) with the level of coordination (LEMOCOT) of the paretic leg. Duration of this facilitation was also correlated (r = -0.58, P = 0.024) with the level of motor recovery (CMSA). These results confirm changes in transmission in heteronymous spinal pathways that are related to motor deficits after stroke.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19122816</pmid><doi>10.1371/journal.pone.0004123</doi><tpages>e4123</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2009-01, Vol.4 (1), p.e4123-e4123
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1289573086
source Open Access: PubMed Central; Publicly Available Content Database (Proquest) (PQ_SDU_P3)
subjects Adult
Aged
Ankle
Ataxia - etiology
Ataxia - physiopathology
Case-Control Studies
Coordination
Female
Femoral Nerve - physiopathology
Femur
Humans
Inhibition
Knee
Leg - innervation
Leg - physiopathology
Legs
Male
Middle Aged
Motor activity
Motor Neurons - physiology
Muscle Spasticity - etiology
Muscle Spasticity - physiopathology
Muscle, Skeletal - innervation
Muscle, Skeletal - physiopathology
Muscles
Neural Pathways - physiopathology
Neurological Disorders/Cerebrovascular Disease
Neuroscience/Motor Systems
Neuroscience/Neuronal Signaling Mechanisms
Paresis - etiology
Paresis - physiopathology
Pathways
Quadriceps muscle
Recovery
Recovery of Function - physiology
Reflex - physiology
Rodents
Spasticity
Stroke
Stroke - complications
Stroke - physiopathology
Tibial Nerve - physiopathology
title Transmission in heteronymous spinal pathways is modified after stroke and related to motor incoordination
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T14%3A32%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transmission%20in%20heteronymous%20spinal%20pathways%20is%20modified%20after%20stroke%20and%20related%20to%20motor%20incoordination&rft.jtitle=PloS%20one&rft.au=Dyer,%20Joseph-Omer&rft.date=2009-01-05&rft.volume=4&rft.issue=1&rft.spage=e4123&rft.epage=e4123&rft.pages=e4123-e4123&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0004123&rft_dat=%3Cgale_plos_%3EA473426270%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c759t-98be352d04df4a9d1c932bafee9006c62afa0042a3e30d40e57d4adc13ea6e193%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1289573086&rft_id=info:pmid/19122816&rft_galeid=A473426270&rfr_iscdi=true