Human TRIM gene expression in response to interferons

Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunit...

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Bibliographic Details
Published in:PloS one 2009-03, Vol.4 (3), p.e4894
Main Authors: Carthagena, Laetitia, Bergamaschi, Anna, Luna, Joseph M, David, Annie, Uchil, Pradeep D, Margottin-Goguet, Florence, Mothes, Walther, Hazan, Uriel, Transy, Catherine, Pancino, Gianfranco, Nisole, Sébastien
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Antiviral activity
Cell activation
Classification
Gene expression
Gene Expression Regulation - drug effects
Genes
Genetic research
HIV
Human immunodeficiency virus
Humans
Immune response
Immune system
Immunity
Immunology
Immunotherapy
Infections
Innate immunity
Interferon
Interferons - pharmacology
Life Sciences
Lymphocytes
Macrophages
Macrophages - drug effects
Macrophages - metabolism
Membrane Proteins - genetics
Monocytes
Pathogenesis
Phylogeny
Promoter Regions, Genetic
Proteins
Reverse Transcriptase Polymerase Chain Reaction
Transcription factors
Viral infections
Virology/Host Antiviral Responses
Virology/Mechanisms of Resistance and Susceptibility, including Host Genetics
Virology/Viral and Gene Regulation
Viruses
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Summary:Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity. To test if TRIM genes are up-regulated during antiviral immune responses, we performed a systematic analysis of TRIM gene expression in human primary lymphocytes and monocyte-derived macrophages in response to interferons (IFNs, type I and II) or following FcgammaR-mediated activation of macrophages. We found that 27 of the 72 human TRIM genes are sensitive to IFN. Our analysis identifies 9 additional TRIM genes that are up-regulated by IFNs, among which only 3 have previously been found to display an antiviral activity. Also, we found 2 TRIM proteins, TRIM9 and 54, to be specifically up-regulated in FcgammaR-activated macrophages. Our results present the first comprehensive TRIM gene expression analysis in primary human immune cells, and suggest the involvement of additional TRIM proteins in regulating host antiviral activities.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0004894