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Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method
Until the 1970s the prevalence of non-venereal trepanomatosis, including yaws, was greatly reduced after worldwide mass treatment. In 2005, cases were again reported in the Democratic Republic of the Congo. We carried out a survey to estimate the village-level prevalence of yaws in the region of Equ...
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| Published in: | PloS one 2009-07, Vol.4 (7), p.e6338-e6338 |
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| container_issue | 7 |
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| container_title | PloS one |
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| creator | Gerstl, Sibylle Kiwila, Gédeon Dhorda, Mehul Lonlas, Sylvaine Myatt, Mark Ilunga, Benoît Kebela Lemasson, Denis Szumilin, Elisabeth Guerin, Philippe J Ferradini, Laurent |
| description | Until the 1970s the prevalence of non-venereal trepanomatosis, including yaws, was greatly reduced after worldwide mass treatment. In 2005, cases were again reported in the Democratic Republic of the Congo. We carried out a survey to estimate the village-level prevalence of yaws in the region of Equator in the north of the country in order to define appropriate strategies to effectively treat the affected population.
We designed a community-based survey using the Lot Quality Assurance Sampling method to classify the prevalence of active yaws in 14 groups of villages (lots). The classification into high, moderate, or low yaws prevalence corresponded to World Health Organization prevalence thresholds for identifying appropriate operational treatment strategies. Active yaws cases were defined by suggestive clinical signs and positive rapid plasma reagin and Treponema pallidum hemagglutination serological tests. The overall prevalence in the study area was 4.7% (95% confidence interval: 3.4-6.0). Two of 14 lots had high prevalence (>10%), three moderate prevalence (5-10%) and nine low prevalence ( |
| doi_str_mv | 10.1371/journal.pone.0006338 |
| format | article |
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We designed a community-based survey using the Lot Quality Assurance Sampling method to classify the prevalence of active yaws in 14 groups of villages (lots). The classification into high, moderate, or low yaws prevalence corresponded to World Health Organization prevalence thresholds for identifying appropriate operational treatment strategies. Active yaws cases were defined by suggestive clinical signs and positive rapid plasma reagin and Treponema pallidum hemagglutination serological tests. The overall prevalence in the study area was 4.7% (95% confidence interval: 3.4-6.0). Two of 14 lots had high prevalence (>10%), three moderate prevalence (5-10%) and nine low prevalence (<5%.).
Although yaws is no longer a World Health Organization priority disease, the presence of yaws in a region where it was supposed to be eradicated demonstrates the importance of continued surveillance and control efforts. Yaws should remain a public health priority in countries where previously it was known to be endemic. The integration of sensitive surveillance systems together with free access to effective treatment is recommended. As a consequence of our study results, more than 16,000 people received free treatment against yaws.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0006338</identifier><identifier>PMID: 19623266</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Bacterial infections ; Confidence intervals ; Democratic Republic of the Congo - epidemiology ; Disease ; Epidemiology ; Equatorial regions ; Evidence-Based Healthcare/Methods for Diagnostic and Therapeutic Studies ; Health services ; Hemagglutination ; HIV ; Human immunodeficiency virus ; Humans ; Infections ; Infectious Diseases/Bacterial Infections ; Infectious Diseases/Neglected Tropical Diseases ; Infectious Diseases/Skin Infections ; Lot Quality Assurance Sampling ; Methods ; Prevalence ; Public health ; Public Health and Epidemiology/Epidemiology ; Public Health and Epidemiology/Health Policy ; Public Health and Epidemiology/Infectious Diseases ; Quality assurance ; Quality Control ; Reagin ; Rural areas ; Sampling ; Sampling methods ; Serological tests ; Skin ; Surveillance systems ; Surveys ; Syphilis ; System effectiveness ; Treponema ; Treponema pallidum ; Yaws ; Yaws - epidemiology</subject><ispartof>PloS one, 2009-07, Vol.4 (7), p.e6338-e6338</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Gerstl et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Gerstl et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c662t-4441875b75900c65a4920c5c651971707c9fd0377047a3111dd0dc11368846143</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1291057123/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1291057123?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19623266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>von Elm, Erik</contributor><creatorcontrib>Gerstl, Sibylle</creatorcontrib><creatorcontrib>Kiwila, Gédeon</creatorcontrib><creatorcontrib>Dhorda, Mehul</creatorcontrib><creatorcontrib>Lonlas, Sylvaine</creatorcontrib><creatorcontrib>Myatt, Mark</creatorcontrib><creatorcontrib>Ilunga, Benoît Kebela</creatorcontrib><creatorcontrib>Lemasson, Denis</creatorcontrib><creatorcontrib>Szumilin, Elisabeth</creatorcontrib><creatorcontrib>Guerin, Philippe J</creatorcontrib><creatorcontrib>Ferradini, Laurent</creatorcontrib><title>Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Until the 1970s the prevalence of non-venereal trepanomatosis, including yaws, was greatly reduced after worldwide mass treatment. In 2005, cases were again reported in the Democratic Republic of the Congo. We carried out a survey to estimate the village-level prevalence of yaws in the region of Equator in the north of the country in order to define appropriate strategies to effectively treat the affected population.
We designed a community-based survey using the Lot Quality Assurance Sampling method to classify the prevalence of active yaws in 14 groups of villages (lots). The classification into high, moderate, or low yaws prevalence corresponded to World Health Organization prevalence thresholds for identifying appropriate operational treatment strategies. Active yaws cases were defined by suggestive clinical signs and positive rapid plasma reagin and Treponema pallidum hemagglutination serological tests. The overall prevalence in the study area was 4.7% (95% confidence interval: 3.4-6.0). Two of 14 lots had high prevalence (>10%), three moderate prevalence (5-10%) and nine low prevalence (<5%.).
Although yaws is no longer a World Health Organization priority disease, the presence of yaws in a region where it was supposed to be eradicated demonstrates the importance of continued surveillance and control efforts. Yaws should remain a public health priority in countries where previously it was known to be endemic. The integration of sensitive surveillance systems together with free access to effective treatment is recommended. As a consequence of our study results, more than 16,000 people received free treatment against yaws.</description><subject>Analysis</subject><subject>Bacterial infections</subject><subject>Confidence intervals</subject><subject>Democratic Republic of the Congo - epidemiology</subject><subject>Disease</subject><subject>Epidemiology</subject><subject>Equatorial regions</subject><subject>Evidence-Based Healthcare/Methods for Diagnostic and Therapeutic Studies</subject><subject>Health services</subject><subject>Hemagglutination</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious Diseases/Bacterial Infections</subject><subject>Infectious Diseases/Neglected Tropical Diseases</subject><subject>Infectious Diseases/Skin Infections</subject><subject>Lot Quality Assurance Sampling</subject><subject>Methods</subject><subject>Prevalence</subject><subject>Public health</subject><subject>Public Health and Epidemiology/Epidemiology</subject><subject>Public Health and Epidemiology/Health Policy</subject><subject>Public Health and Epidemiology/Infectious Diseases</subject><subject>Quality assurance</subject><subject>Quality Control</subject><subject>Reagin</subject><subject>Rural areas</subject><subject>Sampling</subject><subject>Sampling methods</subject><subject>Serological tests</subject><subject>Skin</subject><subject>Surveillance systems</subject><subject>Surveys</subject><subject>Syphilis</subject><subject>System effectiveness</subject><subject>Treponema</subject><subject>Treponema pallidum</subject><subject>Yaws</subject><subject>Yaws - 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epidemiology</topic><topic>Disease</topic><topic>Epidemiology</topic><topic>Equatorial regions</topic><topic>Evidence-Based Healthcare/Methods for Diagnostic and Therapeutic Studies</topic><topic>Health services</topic><topic>Hemagglutination</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious Diseases/Bacterial Infections</topic><topic>Infectious Diseases/Neglected Tropical Diseases</topic><topic>Infectious Diseases/Skin Infections</topic><topic>Lot Quality Assurance Sampling</topic><topic>Methods</topic><topic>Prevalence</topic><topic>Public health</topic><topic>Public Health and Epidemiology/Epidemiology</topic><topic>Public Health and Epidemiology/Health Policy</topic><topic>Public Health and Epidemiology/Infectious Diseases</topic><topic>Quality assurance</topic><topic>Quality Control</topic><topic>Reagin</topic><topic>Rural areas</topic><topic>Sampling</topic><topic>Sampling methods</topic><topic>Serological tests</topic><topic>Skin</topic><topic>Surveillance systems</topic><topic>Surveys</topic><topic>Syphilis</topic><topic>System effectiveness</topic><topic>Treponema</topic><topic>Treponema pallidum</topic><topic>Yaws</topic><topic>Yaws - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerstl, Sibylle</au><au>Kiwila, Gédeon</au><au>Dhorda, Mehul</au><au>Lonlas, Sylvaine</au><au>Myatt, Mark</au><au>Ilunga, Benoît Kebela</au><au>Lemasson, Denis</au><au>Szumilin, Elisabeth</au><au>Guerin, Philippe J</au><au>Ferradini, Laurent</au><au>von Elm, Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2009-07-22</date><risdate>2009</risdate><volume>4</volume><issue>7</issue><spage>e6338</spage><epage>e6338</epage><pages>e6338-e6338</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Until the 1970s the prevalence of non-venereal trepanomatosis, including yaws, was greatly reduced after worldwide mass treatment. In 2005, cases were again reported in the Democratic Republic of the Congo. We carried out a survey to estimate the village-level prevalence of yaws in the region of Equator in the north of the country in order to define appropriate strategies to effectively treat the affected population.
We designed a community-based survey using the Lot Quality Assurance Sampling method to classify the prevalence of active yaws in 14 groups of villages (lots). The classification into high, moderate, or low yaws prevalence corresponded to World Health Organization prevalence thresholds for identifying appropriate operational treatment strategies. Active yaws cases were defined by suggestive clinical signs and positive rapid plasma reagin and Treponema pallidum hemagglutination serological tests. The overall prevalence in the study area was 4.7% (95% confidence interval: 3.4-6.0). Two of 14 lots had high prevalence (>10%), three moderate prevalence (5-10%) and nine low prevalence (<5%.).
Although yaws is no longer a World Health Organization priority disease, the presence of yaws in a region where it was supposed to be eradicated demonstrates the importance of continued surveillance and control efforts. Yaws should remain a public health priority in countries where previously it was known to be endemic. The integration of sensitive surveillance systems together with free access to effective treatment is recommended. As a consequence of our study results, more than 16,000 people received free treatment against yaws.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19623266</pmid><doi>10.1371/journal.pone.0006338</doi><tpages>e6338</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2009-07, Vol.4 (7), p.e6338-e6338 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1291057123 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Analysis Bacterial infections Confidence intervals Democratic Republic of the Congo - epidemiology Disease Epidemiology Equatorial regions Evidence-Based Healthcare/Methods for Diagnostic and Therapeutic Studies Health services Hemagglutination HIV Human immunodeficiency virus Humans Infections Infectious Diseases/Bacterial Infections Infectious Diseases/Neglected Tropical Diseases Infectious Diseases/Skin Infections Lot Quality Assurance Sampling Methods Prevalence Public health Public Health and Epidemiology/Epidemiology Public Health and Epidemiology/Health Policy Public Health and Epidemiology/Infectious Diseases Quality assurance Quality Control Reagin Rural areas Sampling Sampling methods Serological tests Skin Surveillance systems Surveys Syphilis System effectiveness Treponema Treponema pallidum Yaws Yaws - epidemiology |
| title | Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T22%3A47%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20study%20of%20yaws%20in%20the%20Democratic%20Republic%20of%20Congo%20using%20the%20lot%20quality%20assurance%20sampling%20method&rft.jtitle=PloS%20one&rft.au=Gerstl,%20Sibylle&rft.date=2009-07-22&rft.volume=4&rft.issue=7&rft.spage=e6338&rft.epage=e6338&rft.pages=e6338-e6338&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0006338&rft_dat=%3Cgale_plos_%3EA472946657%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c662t-4441875b75900c65a4920c5c651971707c9fd0377047a3111dd0dc11368846143%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1291057123&rft_id=info:pmid/19623266&rft_galeid=A472946657&rfr_iscdi=true |