Associations between an obesity related genetic variant (FTO rs9939609) and prostate cancer risk

Observational studies suggest that obese men have a lower risk of incident prostate cancer, but an increased risk of advanced and fatal cancers. These observations could be due to confounding, detection bias, or a biological effect of obesity. Genetic studies are less susceptible to confounding than...

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Bibliographic Details
Published in:PloS one 2010-10, Vol.5 (10), p.e13485-e13485
Main Authors: Lewis, Sarah J, Murad, Ali, Chen, Lina, Davey Smith, George, Donovan, Jenny, Palmer, Tom, Hamdy, Freddie, Neal, David, Lane, J Athene, Davis, Michael, Cox, Angela, Martin, Richard M
Format: Article
Language:English
Subjects:
Aged
Alleles
Bias
Biological effects
Body mass
Body Mass Index
Cancer
Cancer research
Case-Control Studies
Confidence intervals
Data processing
Development and progression
Epidemiology
Family medicine
Gene polymorphism
Genetic aspects
Genetic diversity
Genetic variance
Genetic Variation
Genetics and Genomics/Complex Traits
Genotype
Health risk assessment
Health risks
Humans
Male
Middle Aged
Obesity
Obesity - complications
Obesity - genetics
Polymorphism
Prostate cancer
Prostate specific antigen
Prostate-Specific Antigen - blood
Prostatic Neoplasms - complications
Prostatic Neoplasms - genetics
Public Health and Epidemiology
Risk
Risk Factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Type 2 diabetes
Urology/Prostate Cancer
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Summary:Observational studies suggest that obese men have a lower risk of incident prostate cancer, but an increased risk of advanced and fatal cancers. These observations could be due to confounding, detection bias, or a biological effect of obesity. Genetic studies are less susceptible to confounding than observational epidemiology and can suggest how associations between phenotypes (such as obesity) and diseases arise. To determine whether the associations between obesity and prostate cancer are causal, we conducted a genetic association study of the relationship between a single nucleotide polymorphism known to be associated with obesity (FTO rs9939609) and prostate cancer. Data are from a population-based sample of 1550 screen-detected prostate cancers, 1815 age- and general practice matched controls with unrestricted prostate specific antigen (PSA) values and 1175 low-PSA controls (PSA
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0013485