Variation in LPA is associated with Lp(a) levels in three populations from the Third National Health and Nutrition Examination Survey

The distribution of lipoprotein(a) [Lp(a)] levels can differ dramatically across diverse racial/ethnic populations. The extent to which genetic variation in LPA can explain these differences is not fully understood. To explore this, 19 LPA tagSNPs were genotyped in 7,159 participants from the Third...

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Bibliographic Details
Published in:PloS one 2011-01, Vol.6 (1), p.e16604
Main Authors: Dumitrescu, Logan, Glenn, Kimberly, Brown-Gentry, Kristin, Shephard, Cynthia, Wong, Michelle, Rieder, Mark J, Smith, Joshua D, Nickerson, Deborah A, Crawford, Dana C
Format: Article
Language:English
Subjects:
African Americans
Apolipoproteins
Biology
Biophysics
Black People - genetics
Cardiovascular disease
Deoxyribonucleic acid
Disease control
DNA
Genetic diversity
Genetic research
Genetic Variation
Genetics
Genomes
Genomics
Genotype
Genotype & phenotype
Health surveys
Hispanic Americans
Hispanic or Latino - genetics
Humans
Lipoprotein A
Lipoprotein(a) - blood
Lipoprotein(a) - genetics
Lipoproteins
Medicine
Minority & ethnic groups
Nutrition
Physiology
Polymorphism
Polymorphism, Single Nucleotide
Population
Population Groups - genetics
Populations
Procedure manuals
Single-nucleotide polymorphism
Social and Behavioral Sciences
Studies
Subpopulations
Surveys
White People - genetics
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Summary:The distribution of lipoprotein(a) [Lp(a)] levels can differ dramatically across diverse racial/ethnic populations. The extent to which genetic variation in LPA can explain these differences is not fully understood. To explore this, 19 LPA tagSNPs were genotyped in 7,159 participants from the Third National Health and Nutrition Examination Survey (NHANES III). NHANES III is a diverse population-based survey with DNA samples linked to hundreds of quantitative traits, including serum Lp(a). Tests of association between LPA variants and transformed Lp(a) levels were performed across the three different NHANES subpopulations (non-Hispanic whites, non-Hispanic blacks, and Mexican Americans). At a significance threshold of p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0016604