HIVToolbox, an integrated web application for investigating HIV

Many bioinformatic databases and applications focus on a limited domain of knowledge federating links to information in other databases. This segregated data structure likely limits our ability to investigate and understand complex biological systems. To facilitate research, therefore, we have built...

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Bibliographic Details
Published in:PloS one 2011-05, Vol.6 (5), p.e20122-e20122
Main Authors: Sargeant, David, Deverasetty, Sandeep, Luo, Yang, Villahoz Baleta, Angel, Zobrist, Stephanie, Rathnayake, Viraj, Russo, Jacqueline C, Vyas, Jay, Muesing, Mark A, Schiller, Martin R
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Binding Sites
Biology
Case studies
Casein Kinase II - metabolism
Computational Biology - methods
Computer Science
Consortia
Data bases
Data integration
Data processing
Data structures
Databases, Protein
Deoxyribonucleic acid
DNA
Genomes
HIV
HIV Integrase - chemistry
HIV Integrase - metabolism
HIV-1 - enzymology
HIV-1 - physiology
Human immunodeficiency virus
Hypotheses
Infections
Integrase
Internet
Internet software
Investigations
Life sciences
Models, Molecular
Ontology
Pathogens
Phosphorylation
Protein Multimerization
Protein Structure, Quaternary
Proteins
Repositories
Studies
Systems Integration
User-Computer Interface
Viral infections
Viral proteins
Web authoring software
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Description
Summary:Many bioinformatic databases and applications focus on a limited domain of knowledge federating links to information in other databases. This segregated data structure likely limits our ability to investigate and understand complex biological systems. To facilitate research, therefore, we have built HIVToolbox, which integrates much of the knowledge about HIV proteins and allows virologists and structural biologists to access sequence, structure, and functional relationships in an intuitive web application. HIV-1 integrase protein was used as a case study to show the utility of this application. We show how data integration facilitates identification of new questions and hypotheses much more rapid and convenient than current approaches using isolated repositories. Several new hypotheses for integrase were created as an example, and we experimentally confirmed a predicted CK2 phosphorylation site. Weblink: [http://hivtoolbox.bio-toolkit.com].
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0020122