Altered error processing following vascular thalamic damage: evidence from an antisaccade task

Event-related potentials (ERP) research has identified a negative deflection within about 100 to 150 ms after an erroneous response--the error-related negativity (ERN)--as a correlate of awareness-independent error processing. The short latency suggests an internal error monitoring system acting rap...

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Published in:PloS one 2011-06, Vol.6 (6), p.e21517-e21517
Main Authors: Peterburs, Jutta, Pergola, Giulio, Koch, Benno, Schwarz, Michael, Hoffmann, Klaus-Peter, Daum, Irene, Bellebaum, Christian
Format: Article
Language:English
Subjects:
Adaptation
Adult
Age
Attenuation
Awareness - physiology
Behavior
Biology
Brain research
Case-Control Studies
Damage detection
Dopamine
Electroencephalography
Error analysis
Error correction & detection
Event-related potentials
Evoked Potentials - physiology
Eye
Eye movements
Feedback
Female
Humans
Information processing
Intelligence Tests
Latency
Magnetic Resonance Imaging
Male
Medical research
Medicine
Memory, Short-Term - physiology
Middle Aged
Mismatch negativity
Monitoring
Monitoring systems
Monkeys
Neurology
Neuropsychology
Neurosciences
Patients
Relaying
Saccades (Eye movements)
Saccades - physiology
Saccadic eye movements
Stereotaxic Techniques
Task Performance and Analysis
Thalamus
Thalamus - blood supply
Thalamus - pathology
Thalamus - physiopathology
Time Factors
Transcranial magnetic stimulation
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cited_by cdi_FETCH-LOGICAL-c757t-d111dd9d4cd7db3ad51c5ec1d5db69765f50f3712fc0b5e162f1c5f0dcdfe5e13
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Koch, Benno
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Daum, Irene
Bellebaum, Christian
description Event-related potentials (ERP) research has identified a negative deflection within about 100 to 150 ms after an erroneous response--the error-related negativity (ERN)--as a correlate of awareness-independent error processing. The short latency suggests an internal error monitoring system acting rapidly based on central information such as an efference copy signal. Studies on monkeys and humans have identified the thalamus as an important relay station for efference copy signals of ongoing saccades. The present study investigated error processing on an antisaccade task with ERPs in six patients with focal vascular damage to the thalamus and 28 control subjects. ERN amplitudes were significantly reduced in the patients, with the strongest ERN attenuation being observed in two patients with right mediodorsal and ventrolateral and bilateral ventrolateral damage, respectively. Although the number of errors was significantly higher in the thalamic lesion patients, the degree of ERN attenuation did not correlate with the error rate in the patients. The present data underline the role of the thalamus for the online monitoring of saccadic eye movements, albeit not providing unequivocal evidence in favour of an exclusive role of a particular thalamic site being involved in performance monitoring. By relaying saccade-related efference copy signals, the thalamus appears to enable fast error processing. Furthermore early error processing based on internal information may contribute to error awareness which was reduced in the patients.
doi_str_mv 10.1371/journal.pone.0021517
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subjects Adaptation
Adult
Age
Attenuation
Awareness - physiology
Behavior
Biology
Brain research
Case-Control Studies
Damage detection
Dopamine
Electroencephalography
Error analysis
Error correction & detection
Event-related potentials
Evoked Potentials - physiology
Eye
Eye movements
Feedback
Female
Humans
Information processing
Intelligence Tests
Latency
Magnetic Resonance Imaging
Male
Medical research
Medicine
Memory, Short-Term - physiology
Middle Aged
Mismatch negativity
Monitoring
Monitoring systems
Monkeys
Neurology
Neuropsychology
Neurosciences
Patients
Relaying
Saccades (Eye movements)
Saccades - physiology
Saccadic eye movements
Stereotaxic Techniques
Task Performance and Analysis
Thalamus
Thalamus - blood supply
Thalamus - pathology
Thalamus - physiopathology
Time Factors
Transcranial magnetic stimulation
title Altered error processing following vascular thalamic damage: evidence from an antisaccade task
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