A high red blood cell distribution width predicts failure of arteriovenous fistula

In hemodialysis patients, a native arteriovenous fistula (AVF) is the preferred form of permanent vascular access. Despite recent improvements, vascular access dysfunction remains an important cause of morbidity in these patients. In this prospective observational cohort study, we evaluated potentia...

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Bibliographic Details
Published in:PloS one 2012-05, Vol.7 (5), p.e36482-e36482
Main Authors: Bojakowski, Krzysztof, Dzabic, Mensur, Kurzejamska, Ewa, Styczynski, Grzegorz, Andziak, Piotr, Gaciong, Zbigniew, Söderberg-Nauclér, Cecilia, Religa, Piotr
Format: Article
Language:English
Subjects:
Aged
Analysis
Arteriovenous fistula
Arteriovenous Fistula - blood
Arteriovenous Fistula - surgery
Biology
Biomarkers - blood
Biomarkers - metabolism
Blood
Blood cells
Blood vessels
CD45 antigen
Chronic illnesses
Cohort Studies
Confidence intervals
Dialysis
Erythrocyte Count
Erythrocytes
Failure analysis
Female
Fistulae
Hazard identification
Hemodialysis
Humans
Inflammation
Kidney diseases
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - surgery
Kidney Failure, Chronic - therapy
Kidney transplantation
Leukocyte Count
Leukocytes
Male
Medical research
Medicin och hälsovetenskap
Medicine
Middle Aged
Monocytes
Monocytes - cytology
Morbidity
Mortality
Parameter identification
Patients
Prospective Studies
Radial Artery - cytology
Radial Artery - surgery
Renal Dialysis - methods
Risk analysis
Risk Factors
Statistical models
Surgery
Time Factors
Treatment Failure
Veins & arteries
Veins - cytology
Veins - surgery
White blood cell count
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Summary:In hemodialysis patients, a native arteriovenous fistula (AVF) is the preferred form of permanent vascular access. Despite recent improvements, vascular access dysfunction remains an important cause of morbidity in these patients. In this prospective observational cohort study, we evaluated potential risk factors for native AVF dysfunction. We included 68 patients with chronic renal disease stage 5 eligible for AVF construction at the Department of General and Vascular Surgery, Central Clinical Hospital Ministry of Internal Affairs, Warsaw, Poland. Patient characteristics and biochemical parameters associated with increased risk for AVF failure were identified using Cox proportional hazards models. Vessel biopsies were analyzed for inflammatory cells and potential associations with biochemical parameters. In multivariable analysis, independent predictors of AVF dysfunction were the number of white blood cells (hazard ratio [HR] 1.67; 95% confidence interval [CI] 1.24 to 2.25; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0036482