Genetic copy number variation and general cognitive ability

Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disord...

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Bibliographic Details
Published in:PloS one 2012-12, Vol.7 (12), p.e37385-e37385
Main Authors: MacLeod, Andrew K, Davies, Gail, Payton, Antony, Tenesa, Albert, Harris, Sarah E, Liewald, David, Ke, Xiayi, Luciano, Michelle, Lopez, Lorna M, Gow, Alan J, Corley, Janie, Redmond, Paul, McNeill, Geraldine, Pickles, Andrew, Ollier, William, Horan, Michael, Starr, John M, Pendleton, Neil, Thomson, Pippa A, Porteous, David J, Deary, Ian J
Format: Article
Language:English
Subjects:
Ability tests
Aged
Aging
Aging - genetics
Algorithms
Attention deficit hyperactivity disorder
Autism
Batteries
Biology
Childrens health
Cognition
Cognition - physiology
Cognitive ability
Copy number
Crystallization
Disease susceptibility
Disorders
DNA Copy Number Variations - genetics
Elderly
Epidemiology
Female
Genetic diversity
Genetics
Genomes
Humans
Hyperactivity
Intelligence
Longitudinal Studies
Male
Medical research
Medicine
Mental disorders
Mental Disorders - genetics
Morbidity
Mutation
Nerve Tissue Proteins - genetics
Neurodegeneration
Older people
Phenotype
Reproduction (copying)
Schizophrenia
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Summary:Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested that these deletions or duplications may be associated with differences in intelligence. Here we investigate associations between large (≥500kb), rare (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0037385