Pharmacometabolomics reveals racial differences in response to atenolol treatment

Antihypertensive drugs are among the most commonly prescribed drugs for chronic disease worldwide. The response to antihypertensive drugs varies substantially between individuals and important factors such as race that contribute to this heterogeneity are poorly understood. In this study we use meta...

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Bibliographic Details
Published in:PloS one 2013-03, Vol.8 (3), p.e57639-e57639
Main Authors: Wikoff, William R, Frye, Reginald F, Zhu, Hongjie, Gong, Yan, Boyle, Stephen, Churchill, Erik, Cooper-Dehoff, Rhonda M, Beitelshees, Amber L, Chapman, Arlene B, Fiehn, Oliver, Johnson, Julie A, Kaddurah-Daouk, Rima
Format: Article
Language:English
Subjects:
Adrenergic receptors
Adult
African Americans
African Americans - genetics
Amino acids
Analysis
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Antihypertensives
Atenolol
Atenolol - pharmacology
Atenolol - therapeutic use
Biology
Chronic diseases
Chronic illnesses
Cluster Analysis
Cultural differences
Diabetes
Drug therapy
Drugs
Ethnicity
European Continental Ancestry Group - genetics
Fatty acids
Female
Genetic diversity
Genomes
Genomics
Heterogeneity
Humans
Hypertension
Hypertension - drug therapy
Hypertension - ethnology
Hypertension - genetics
Hypertension - metabolism
Lipase
Male
Medicine
Metabolic Networks and Pathways - drug effects
Metabolism
Metabolites
Metabolome
Metabolomics
Middle Aged
Minority & ethnic groups
Monounsaturated fatty acids
Oleic acid
Pharmacogenetics
Pharmacology
Polymorphism, Single Nucleotide
Prescriptions (Drugs)
Proteomics
Psychiatry
Race
Racial differences
Risk Factors
Saturated fatty acids
Single-nucleotide polymorphism
Substance abuse treatment
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Summary:Antihypertensive drugs are among the most commonly prescribed drugs for chronic disease worldwide. The response to antihypertensive drugs varies substantially between individuals and important factors such as race that contribute to this heterogeneity are poorly understood. In this study we use metabolomics, a global biochemical approach to investigate biochemical changes induced by the beta-adrenergic receptor blocker atenolol in Caucasians and African Americans. Plasma from individuals treated with atenolol was collected at baseline (untreated) and after a 9 week treatment period and analyzed using a GC-TOF metabolomics platform. The metabolomic signature of atenolol exposure included saturated (palmitic), monounsaturated (oleic, palmitoleic) and polyunsaturated (arachidonic, linoleic) free fatty acids, which decreased in Caucasians after treatment but were not different in African Americans (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0057639