Chicken cathelicidins display antimicrobial activity against multiresistant bacteria without inducing strong resistance

The increased prevalence of multidrug-resistant (MDR) bacteria in combination with the relatively limited development of new antibiotics presents a serious threat to public health. In chicken, especially Extended-Spectrum ß-Lactamase (ESBL) carrying Enterobacteriaceae are often asymptomatically pres...

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Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4), p.e61964-e61964
Main Authors: Veldhuizen, Edwin J A, Brouwer, Ellen C, Schneider, Viktoria A F, Fluit, Ad C
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibacterial agents
Antibiotics
Antimicrobial activity
Antimicrobial agents
Antimicrobial Cationic Peptides - chemistry
Antimicrobial Cationic Peptides - pharmacology
Bacteria
Bacteria - drug effects
Beta lactamases
Biology
Cathelicidins
Chickens
Contamination
Drug resistance
Drug Resistance, Bacterial - drug effects
Drug Resistance, Multiple - drug effects
Health aspects
Health risks
Humans
Immunology
Infectious diseases
Laboratories
Localization
Medicine
Microbial drug resistance
Microbial Sensitivity Tests
Molecular Sequence Data
Multidrug resistance
Peptides
Pneumonia
Public health
Staphylococcus infections
Studies
Veterinary medicine
Veterinary Science
β Lactamase
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Summary:The increased prevalence of multidrug-resistant (MDR) bacteria in combination with the relatively limited development of new antibiotics presents a serious threat to public health. In chicken, especially Extended-Spectrum ß-Lactamase (ESBL) carrying Enterobacteriaceae are often asymptomatically present but can infect humans. Due to their broad range antimicrobial activity cathelicidins and other host defence peptides, are considered to be an attractive alternative to conventional antibiotics. In this study, the antimicrobial activity of three chicken cathelicidins against a broad array of multidrug resistant bacteria was determined. All three peptides showed high antibacterial activity independent of the presence of MDR characteristics. Induction experiments using S. aureus and K. pneumoniae showed that although an increase in resistance was initially observed, susceptibility towards chicken cathelicidins remained high and no major resistance was developed. The combined results underline the potential of chicken cathelicidins as a new alternative to antibiotics.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0061964