Mild obesity, physical activity, calorie intake, and the risks of cervical intraepithelial neoplasia and cervical cancer

We investigated whether obesity, physical activity, and calorie intake are associated with the risks of cervical intraepithelial neoplasia (CIN) and cervical cancer. We enrolled 1125 women (age, 18-65 years) into a human papillomavirus cohort study established from 2006 to 2012. Multinomial logistic...

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Published in:PloS one 2013-06, Vol.8 (6), p.e66555-e66555
Main Authors: Lee, Jae Kwan, So, Kyeong A, Piyathilake, Chandrika J, Kim, Mi Kyung
Format: Article
Language:English
Subjects:
Adult
Alcohol use
Body mass
Body Mass Index
Body size
Body weight
Cancer
Cervical cancer
Cervical Intraepithelial Neoplasia - epidemiology
Cervical Intraepithelial Neoplasia - etiology
Cervical Intraepithelial Neoplasia - prevention & control
Cervix
Cervix dysplasia
Confidence intervals
Development and progression
Endometrial cancer
Energy Intake - physiology
Exercise
Female
Health aspects
Health risk assessment
Health risks
Human papillomavirus
Humans
Logistic Models
Medicine
Middle Aged
Motor Activity - physiology
Obesity
Obesity - complications
Odds Ratio
Overweight
Papillomavirus infections
Physical activity
Regression analysis
Regression models
Risk Factors
Statistical analysis
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - etiology
Uterine Cervical Neoplasms - prevention & control
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Piyathilake, Chandrika J
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description We investigated whether obesity, physical activity, and calorie intake are associated with the risks of cervical intraepithelial neoplasia (CIN) and cervical cancer. We enrolled 1125 women (age, 18-65 years) into a human papillomavirus cohort study established from 2006 to 2012. Multinomial logistic regression models were used to estimate crude and multivariate odds ratios (ORs) and the corresponding 95% confidence intervals (95% CIs), and to assess whether body mass index (BMI), height, weight, total calorie intake, and physical activity were associated with the risks of CIN and cervical cancer. Cervical cancer risk was positively associated with BMI and inversely associated with physical activity. When compared with women with a normal BMI (18.5-23 kg/m(2)), the multivariate ORs (95% CIs) for those overweight (23-25 kg/m(2)) and mild obesity (≥25 kg/m(2)) were 1.25 (0.79-2.00) and 1.70 (1.10-2.63), respectively. When compared with women with the lowest tertile of physical activity (
doi_str_mv 10.1371/journal.pone.0066555
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We enrolled 1125 women (age, 18-65 years) into a human papillomavirus cohort study established from 2006 to 2012. Multinomial logistic regression models were used to estimate crude and multivariate odds ratios (ORs) and the corresponding 95% confidence intervals (95% CIs), and to assess whether body mass index (BMI), height, weight, total calorie intake, and physical activity were associated with the risks of CIN and cervical cancer. Cervical cancer risk was positively associated with BMI and inversely associated with physical activity. When compared with women with a normal BMI (18.5-23 kg/m(2)), the multivariate ORs (95% CIs) for those overweight (23-25 kg/m(2)) and mild obesity (≥25 kg/m(2)) were 1.25 (0.79-2.00) and 1.70 (1.10-2.63), respectively. When compared with women with the lowest tertile of physical activity (&lt;38.5 MET-hours/week), the ORs (95% CIs) for cervical cancer were 0.95 (0.61-1.48) and 0.61 (0.38-0.98) for women with medium physical activity (38.5-71.9 MET-hours/week) and those with high physical activity (72 MET-hours/week), respectively (p for linear trend  = 0.03). The CIN2/3 risk was inversely associated with physical activity after adjustment for confounders. Compared with women with low physical activity (&lt; 38.5 MET-hours/week), the ORs (95% CIs) for CIN2/3 were 0.64 (0.40-1.01) and 0.58 (0.36-0.93) for the medium and high physical activity groups, respectively (p for linear trend  = 0.02). Total calorie intake was not statistically associated with the risks of CIN and cervical cancer after adjustment for confounders. 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We enrolled 1125 women (age, 18-65 years) into a human papillomavirus cohort study established from 2006 to 2012. Multinomial logistic regression models were used to estimate crude and multivariate odds ratios (ORs) and the corresponding 95% confidence intervals (95% CIs), and to assess whether body mass index (BMI), height, weight, total calorie intake, and physical activity were associated with the risks of CIN and cervical cancer. Cervical cancer risk was positively associated with BMI and inversely associated with physical activity. When compared with women with a normal BMI (18.5-23 kg/m(2)), the multivariate ORs (95% CIs) for those overweight (23-25 kg/m(2)) and mild obesity (≥25 kg/m(2)) were 1.25 (0.79-2.00) and 1.70 (1.10-2.63), respectively. When compared with women with the lowest tertile of physical activity (&lt;38.5 MET-hours/week), the ORs (95% CIs) for cervical cancer were 0.95 (0.61-1.48) and 0.61 (0.38-0.98) for women with medium physical activity (38.5-71.9 MET-hours/week) and those with high physical activity (72 MET-hours/week), respectively (p for linear trend  = 0.03). The CIN2/3 risk was inversely associated with physical activity after adjustment for confounders. Compared with women with low physical activity (&lt; 38.5 MET-hours/week), the ORs (95% CIs) for CIN2/3 were 0.64 (0.40-1.01) and 0.58 (0.36-0.93) for the medium and high physical activity groups, respectively (p for linear trend  = 0.02). Total calorie intake was not statistically associated with the risks of CIN and cervical cancer after adjustment for confounders. Our results indicate that in addition to screening for and treatment of CIN, recommendations on the maintenance of an appropriate BMI with an emphasis on physical activity could be an important preventive strategy against the development of cervical cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23776686</pmid><doi>10.1371/journal.pone.0066555</doi><tpages>e66555</tpages><oa>free_for_read</oa></addata></record>
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1932-6203
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source PMC (PubMed Central); Publicly Available Content (ProQuest)
subjects Adult
Alcohol use
Body mass
Body Mass Index
Body size
Body weight
Cancer
Cervical cancer
Cervical Intraepithelial Neoplasia - epidemiology
Cervical Intraepithelial Neoplasia - etiology
Cervical Intraepithelial Neoplasia - prevention & control
Cervix
Cervix dysplasia
Confidence intervals
Development and progression
Endometrial cancer
Energy Intake - physiology
Exercise
Female
Health aspects
Health risk assessment
Health risks
Human papillomavirus
Humans
Logistic Models
Medicine
Middle Aged
Motor Activity - physiology
Obesity
Obesity - complications
Odds Ratio
Overweight
Papillomavirus infections
Physical activity
Regression analysis
Regression models
Risk Factors
Statistical analysis
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - etiology
Uterine Cervical Neoplasms - prevention & control
title Mild obesity, physical activity, calorie intake, and the risks of cervical intraepithelial neoplasia and cervical cancer
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