Procalcitonin guidance to reduce antibiotic treatment of lower respiratory tract infection in children and adolescents (ProPAED): a randomized controlled trial

• Published in: PloS one 2013-08, Vol.8 (8), p.e68419-e68419
• Main Authors: Baer, Gurli, Baumann, Philipp, Buettcher, Michael, Heininger, Ulrich, Berthet, Gerald, Schäfer, Juliane, Bucher, Heiner C, Trachsel, Daniel, Schneider, Jacques, Gambon, Muriel, Reppucci, Diana, Bonhoeffer, Jessica M, Stähelin-Massik, Jody, Schuetz, Philipp, Mueller, Beat, Szinnai, Gabor, Schaad, Urs B, Bonhoeffer, Jan
• Format: Article
• Language: English
• Subjects: Adolescent; Adolescents; Age; Algorithms; Analysis; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antimicrobial agents; Bacteria; Bacterial infections; Biology; Biomarkers - blood; Calcitonin - blood; Calcitonin Gene-Related Peptide; Care and treatment; Child; Children; Children & youth; Children's hospitals; Clinical trials; Emergency medical services; Epidemiology; Exposure; Humans; Impairment; Infections; Internal medicine; Medicine; Mortality; Motivation; Patients; Pediatrics; Pneumonia; Practice guidelines (Medicine); Prescription writing; Primary care; Procalcitonin; Protein Precursors - blood; Randomization; Respiratory tract; Respiratory tract diseases; Respiratory tract infection; Respiratory Tract Infections - blood; Respiratory Tract Infections - drug therapy; Teenagers; Treatment Outcome
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0068419

Antibiotics are overused in children and adolescents with lower respiratory tract infection (LRTI). Serum-procalcitonin (PCT) can be used to guide treatment when bacterial infection is suspected. Its role in pediatric LRTI is unclear. Between 01/2009 and 02/2010 we randomized previously healthy patients 1 month to 18 years old presenting with LRTI to the emergency departments of two pediatric hospitals in Switzerland to receive antibiotics either according to a PCT guidance algorithm established for adult LRTI or standard care clinical guidelines. In intention-to-treat analyses, antibiotic prescribing rate, duration of antibiotic treatment, and number of days with impairment of daily activities within 14 days of randomization were compared between the two groups. In total 337 children, mean age 3.8 years (range 0.1-18), were included. Antibiotic prescribing rates were not significantly different in PCT guided patients compared to controls (OR 1.26; 95% CI 0.81, 1.95). Mean duration of antibiotic exposure was reduced from 6.3 to 4.5 days under PCT guidance (-1.8 days; 95% CI -3.1, -0.5; P = 0.039) for all LRTI and from 9.1 to 5.7 days for pneumonia (-3.4 days 95% CI -4.9, -1.7; P