Genome-wide association study reveals genetic architecture of eating behavior in pigs and its implications for humans obesity by comparative mapping

This study was aimed at identifying genomic regions controlling feeding behavior in Danish Duroc boars and its potential implications for eating behavior in humans. Data regarding individual daily feed intake (DFI), total daily time spent in feeder (TPD), number of daily visits to feeder (NVD), aver...

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Published in:PloS one 2013-08, Vol.8 (8), p.e71509-e71509
Main Authors: Do, Duy Ngoc, Strathe, Anders Bjerring, Ostersen, Tage, Jensen, Just, Mark, Thomas, Kadarmideen, Haja N
Format: Article
Language:English
Subjects:
Agriculture
Animal behavior
Animals
Biological effects
Biology
Breeding
Cattle
Chromosome Mapping
Chromosomes, Human - genetics
Chromosomes, Mammalian - genetics
Dephosphorylation
Development and progression
Eating
Eating behavior
Feed conversion
Feed efficiency
Feeding
Feeding Behavior
Feeds
Food habits
Gene expression
Gene mapping
Gene regulation
Genes
Genetic diversity
Genetic improvement
Genetic Markers
Genetic Predisposition to Disease
Genetic variance
Genome, Human - genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomics
Growth hormone-releasing hormone
Haplotypes - genetics
Human behavior
Humans
Kinases
Legal fees
Linkage Disequilibrium - genetics
Mapping
Medicine
Metabolic disorders
Metabolic syndrome
Molecular Sequence Annotation
Obesity
Obesity - genetics
Phenotype
Polymorphism, Single Nucleotide - genetics
Quality Control
Quantitative trait loci
Quantitative Trait Loci - genetics
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
Suidae
Sus scrofa - genetics
Swine
Synapses
Veterinary Science
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Strathe, Anders Bjerring
Ostersen, Tage
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description This study was aimed at identifying genomic regions controlling feeding behavior in Danish Duroc boars and its potential implications for eating behavior in humans. Data regarding individual daily feed intake (DFI), total daily time spent in feeder (TPD), number of daily visits to feeder (NVD), average duration of each visit (TPV), mean feed intake per visit (FPV) and mean feed intake rate (FR) were available for 1130 boars. All boars were genotyped using the Illumina Porcine SNP60 BeadChip. The association analyses were performed using the GenABEL package in the R program. Sixteen SNPs were found to have moderate genome-wide significance (p
doi_str_mv 10.1371/journal.pone.0071509
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Data regarding individual daily feed intake (DFI), total daily time spent in feeder (TPD), number of daily visits to feeder (NVD), average duration of each visit (TPV), mean feed intake per visit (FPV) and mean feed intake rate (FR) were available for 1130 boars. All boars were genotyped using the Illumina Porcine SNP60 BeadChip. The association analyses were performed using the GenABEL package in the R program. Sixteen SNPs were found to have moderate genome-wide significance (p&lt;5E-05) and 76 SNPs had suggestive (p&lt;5E-04) association with feeding behavior traits. MSI2 gene on chromosome (SSC) 14 was very strongly associated with NVD. Thirty-six SNPs were located in genome regions where QTLs have previously been reported for behavior and/or feed intake traits in pigs. The regions: 64-65 Mb on SSC 1, 124-130 Mb on SSC 8, 63-68 Mb on SSC 11, 32-39 Mb and 59-60 Mb on SSC 12 harbored several signifcant SNPs. Synapse genes (GABRR2, PPP1R9B, SYT1, GABRR1, CADPS2, DLGAP2 and GOPC), dephosphorylation genes (PPM1E, DAPP1, PTPN18, PTPRZ1, PTPN4, MTMR4 and RNGTT) and positive regulation of peptide secretion genes (GHRH, NNAT and TCF7L2) were highly significantly associated with feeding behavior traits. This is the first GWAS to identify genetic variants and biological mechanisms for eating behavior in pigs and these results are important for genetic improvement of pig feed efficiency. We have also conducted pig-human comparative gene mapping to reveal key genomic regions and/or genes on the human genome that may influence eating behavior in human beings and consequently affect the development of obesity and metabolic syndrome. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Do, Duy Ngoc</au><au>Strathe, Anders Bjerring</au><au>Ostersen, Tage</au><au>Jensen, Just</au><au>Mark, Thomas</au><au>Kadarmideen, Haja N</au><au>Paschou, Peristera</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-wide association study reveals genetic architecture of eating behavior in pigs and its implications for humans obesity by comparative mapping</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-08-19</date><risdate>2013</risdate><volume>8</volume><issue>8</issue><spage>e71509</spage><epage>e71509</epage><pages>e71509-e71509</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study was aimed at identifying genomic regions controlling feeding behavior in Danish Duroc boars and its potential implications for eating behavior in humans. Data regarding individual daily feed intake (DFI), total daily time spent in feeder (TPD), number of daily visits to feeder (NVD), average duration of each visit (TPV), mean feed intake per visit (FPV) and mean feed intake rate (FR) were available for 1130 boars. All boars were genotyped using the Illumina Porcine SNP60 BeadChip. The association analyses were performed using the GenABEL package in the R program. Sixteen SNPs were found to have moderate genome-wide significance (p&lt;5E-05) and 76 SNPs had suggestive (p&lt;5E-04) association with feeding behavior traits. MSI2 gene on chromosome (SSC) 14 was very strongly associated with NVD. Thirty-six SNPs were located in genome regions where QTLs have previously been reported for behavior and/or feed intake traits in pigs. The regions: 64-65 Mb on SSC 1, 124-130 Mb on SSC 8, 63-68 Mb on SSC 11, 32-39 Mb and 59-60 Mb on SSC 12 harbored several signifcant SNPs. Synapse genes (GABRR2, PPP1R9B, SYT1, GABRR1, CADPS2, DLGAP2 and GOPC), dephosphorylation genes (PPM1E, DAPP1, PTPN18, PTPRZ1, PTPN4, MTMR4 and RNGTT) and positive regulation of peptide secretion genes (GHRH, NNAT and TCF7L2) were highly significantly associated with feeding behavior traits. This is the first GWAS to identify genetic variants and biological mechanisms for eating behavior in pigs and these results are important for genetic improvement of pig feed efficiency. We have also conducted pig-human comparative gene mapping to reveal key genomic regions and/or genes on the human genome that may influence eating behavior in human beings and consequently affect the development of obesity and metabolic syndrome. This is the first translational genomics study of its kind to report potential candidate genes for eating behavior in humans.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23977060</pmid><doi>10.1371/journal.pone.0071509</doi><tpages>e71509</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
ispartof PloS one, 2013-08, Vol.8 (8), p.e71509-e71509
issn 1932-6203
1932-6203
language eng
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source Open Access: PubMed Central; Publicly Available Content Database
subjects Agriculture
Animal behavior
Animals
Biological effects
Biology
Breeding
Cattle
Chromosome Mapping
Chromosomes, Human - genetics
Chromosomes, Mammalian - genetics
Dephosphorylation
Development and progression
Eating
Eating behavior
Feed conversion
Feed efficiency
Feeding
Feeding Behavior
Feeds
Food habits
Gene expression
Gene mapping
Gene regulation
Genes
Genetic diversity
Genetic improvement
Genetic Markers
Genetic Predisposition to Disease
Genetic variance
Genome, Human - genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomics
Growth hormone-releasing hormone
Haplotypes - genetics
Human behavior
Humans
Kinases
Legal fees
Linkage Disequilibrium - genetics
Mapping
Medicine
Metabolic disorders
Metabolic syndrome
Molecular Sequence Annotation
Obesity
Obesity - genetics
Phenotype
Polymorphism, Single Nucleotide - genetics
Quality Control
Quantitative trait loci
Quantitative Trait Loci - genetics
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
Suidae
Sus scrofa - genetics
Swine
Synapses
Veterinary Science
title Genome-wide association study reveals genetic architecture of eating behavior in pigs and its implications for humans obesity by comparative mapping
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