External validation of the derived neutrophil to lymphocyte ratio as a prognostic marker on a large cohort of pancreatic cancer patients

With growing evidence on the role of inflammation in cancer biology, the presence of a systemic inflammatory response has been postulated as having prognostic significance in a wide range of cancer types. The derived neutrophil to lymphocyte ratio (dNLR), which represents an easily determinable pote...

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Bibliographic Details
Published in:PloS one 2013-11, Vol.8 (11), p.e78225-e78225
Main Authors: Szkandera, Joanna, Stotz, Michael, Eisner, Florian, Absenger, Gudrun, Stojakovic, Tatjana, Samonigg, Hellmut, Kornprat, Peter, Schaberl-Moser, Renate, Alzoughbi, Wael, Ress, Anna Lena, Seggewies, Friederike Sophia, Gerger, Armin, Hoefler, Gerald, Pichler, Martin
Format: Article
Language:English
Subjects:
Aged
Analysis
Biomarkers - analysis
Cancer
Cancer patients
Care and treatment
Clinical trials
Cytokines
Female
Granulocytes
Humans
Immunology
Inflammation
Inflammation - diagnosis
Inflammation - immunology
Inflammation - mortality
Inflammation - pathology
Inflammatory response
Kaplan-Meier Estimate
Laboratories
Leukocyte Count
Lung cancer
Lymphocytes
Lymphocytes - immunology
Lymphocytes - pathology
Male
Medical prognosis
Medical research
Medicine
Metastasis
Middle Aged
Multivariate analysis
Neutrophils
Neutrophils - immunology
Neutrophils - pathology
Oncology
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - immunology
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pathology
Patients
Pretreatment
Prognosis
Proportional Hazards Models
Regression analysis
Regression models
Retrospective Studies
ROC Curve
Survival
Tumors
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Summary:With growing evidence on the role of inflammation in cancer biology, the presence of a systemic inflammatory response has been postulated as having prognostic significance in a wide range of cancer types. The derived neutrophil to lymphocyte ratio (dNLR), which represents an easily determinable potential prognostic marker in daily practise and clinical trials, has never been externally validated in pancreatic cancer (PC) patients. Data from 474 consecutive PC patients, treated between 2004 and 2012 at a single centre, were evaluated retrospectively. Cancer-specific survival (CSS) was assessed using the Kaplan-Meier method. To evaluate the prognostic relevance of dNLR, univariate and multivariate Cox regression models were applied. We calculated by ROC analysis a cut-off value of 2.3 for the dNLR to be ideal to discriminate between patients' survival in the whole cohort. Kaplan-Meier curve reveals a dNLR≥2.3 as a factor for decreased CSS in PC patients (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0078225