Effects of vibration in forced posture on biochemical bone metabolism indices, and morphometric and mechanical properties of the lumbar vertebra

Epidemiological studies have shown a relatively strong association between occupational lower back pain (LBP) and long-term exposure to vibration. However, there is limited knowledge of the impact of vibration and sedentariness on bone metabolism of the lumbar vertebra and the mechanism of bone-deri...

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Bibliographic Details
Published in:PloS one 2013-11, Vol.8 (11), p.e78640-e78640
Main Authors: Chang, Qi, Wei, Fuling, Zhang, Li, Ju, Xiaowei, Zhu, Lvgang, Huang, Changlin, Huang, Tao, Zuo, Xincheng, Gao, Chunfang
Format: Article
Language:English
Subjects:
Acid phosphatase
Acid phosphatase (tartrate-resistant)
Acid Phosphatase - blood
Acid resistance
Acids
Alkaline phosphatase
Alkaline Phosphatase - blood
Animals
Back pain
Biomechanical Phenomena
Biomechanics
Bone biomechanics
Bone marrow
Bone turnover
Calcium
Calcium - blood
Calcium ions
Epidemiology
Female
Heavy construction
Hospitals
Isoenzymes - blood
Low Back Pain - etiology
Lumbar Vertebrae - enzymology
Lumbar Vertebrae - metabolism
Male
Mechanical properties
Metabolism
Myelodysplastic syndromes
Occupational exposure
Older people
Organ Specificity
Osteocalcin
Osteocalcin - blood
Osteoporosis
Pain
Phosphatase
Phosphatases
Phosphoric Acids - blood
Physiological aspects
Posture
Rabbits
Restraint, Physical
Science
Serum levels
Spine
Systematic review
Tartrate-Resistant Acid Phosphatase
Vertebra
Vertebrae
Vibration
Vibration - adverse effects
Vibration effects
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Summary:Epidemiological studies have shown a relatively strong association between occupational lower back pain (LBP) and long-term exposure to vibration. However, there is limited knowledge of the impact of vibration and sedentariness on bone metabolism of the lumbar vertebra and the mechanism of bone-derived LBP. The aim of this study was to investigate the effects of vibration in forced posture (a seated posture) on biochemical bone metabolism indices, and morphometric and mechanical properties of the lumbar vertebra, and provide a scientific theoretical basis for the mechanism of bone-derived LBP, serum levels of Ca(2+), (HPO4)(2-), tartrate-resistant acid phosphatase (TRAP), bone-specific alkaline phosphatase (BALP), and bone gla protein (BGP),the pathological changes and biomechanics of lumbar vertebra of New Zealand white rabbits were studied. The results demonstrate that both forced posture and vibration can cause pathological changes to the lumbar vertebra, which can result in bone-derived LBP, and vibration combined with a seated posture could cause further damage to bone metabolism. Serological changes can be used as early markers for clinical diagnosis of bone-derived LBP.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0078640