Unilateral lateral entorhinal inactivation impairs memory expression in trace eyeblink conditioning

Memory in trace eyeblink conditioning is mediated by an inter-connected network that involves the hippocampus (HPC), several neocortical regions, and the cerebellum. This network reorganizes after learning as the center of the network shifts from the HPC to the medial prefrontal cortex (mPFC). Despi...

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Bibliographic Details
Published in:PloS one 2013-12, Vol.8 (12), p.e84543-e84543
Main Authors: Tanninen, Stephanie E, Morrissey, Mark D, Takehara-Nishiuchi, Kaori
Format: Article
Language:English
Subjects:
Animals
Blinking - physiology
Cerebellum
Conditioning
Conditioning (Psychology) - physiology
Cortex
Cortex (entorhinal)
Deactivation
Electrodes
Entorhinal Cortex - physiology
Eyelid conditioning
Hemispheres
Inactivation
Laboratory animals
Learning
Male
Memory
Memory, Long-Term - physiology
Neurosciences
Pharmacology
Prefrontal cortex
Prefrontal Cortex - physiology
Rats
Retention
Rodents
Stainless steel
Surgery
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Summary:Memory in trace eyeblink conditioning is mediated by an inter-connected network that involves the hippocampus (HPC), several neocortical regions, and the cerebellum. This network reorganizes after learning as the center of the network shifts from the HPC to the medial prefrontal cortex (mPFC). Despite the network reorganization, the lateral entorhinal cortex (LEC) plays a stable role in expressing recently acquired HPC-dependent memory as well as remotely acquired mPFC-dependent memory. Entorhinal involvement in recent memory expression may be attributed to its previously proposed interactions with the HPC. In contrast, it remains unknown how the LEC participates in memory expression after the network disengages from the HPC. The present study tested the possibility that the LEC and mPFC functionally interact during remote memory expression by examining the impact of pharmacological inactivation of the LEC in one hemisphere and the mPFC in the contralateral hemisphere on memory expression in rats. Memory expression one day and one month after learning was significantly impaired after LEC-mPFC inactivation; however, the degree of impairment was comparable to that after unilateral LEC inactivation. Unilateral mPFC inactivation had no effect on recent or remote memory expression. These results suggest that the integrity of the LEC in both hemispheres is necessary for memory expression. Functional interactions between the LEC and mPFC should therefore be tested with an alternative design.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0084543