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Pancreatitis-associated protein does not predict disease relapse in inflammatory bowel disease patients

The pancreatitis-associated protein (PAP) is increased in the serum of active inflammatory bowel disease (IBD) patients and its levels seem to be correlated with disease activity. Our aim was to evaluate the usefulness of serum and fecal PAP measurements to predict relapse in patients with inactive...

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Published in:PloS one 2014-01, Vol.9 (1), p.e84957-e84957
Main Authors: Nunes, Tiago, Etchevers, Maria Josefina, Sandi, Maria Jose, Pinó Donnay, Susana, Grandjean, Teddy, Pellisé, Maria, Panés, Julián, Ricart, Elena, Iovanna, Juan Lucio, Dagorn, Jean-Charles, Chamaillard, Mathias, Sans, Miquel
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Language:English
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Summary:The pancreatitis-associated protein (PAP) is increased in the serum of active inflammatory bowel disease (IBD) patients and its levels seem to be correlated with disease activity. Our aim was to evaluate the usefulness of serum and fecal PAP measurements to predict relapse in patients with inactive IBD. We undertook a 12-month prospective study that included 66 Crohn's disease (CD) and 74 ulcerative colitis (UC) patients. At inclusion, patients were in clinical remission, defined by a Harvey-Bradshaw (HB) Index≤4 (CD) or a partial Mayo Score (MS)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0084957