Major burden of severe anemia from non-falciparum malaria species in Southern Papua: a hospital-based surveillance study

The burden of anemia attributable to non-falciparum malarias in regions with Plasmodium co-endemicity is poorly documented. We compared the hematological profile of patients with and without malaria in southern Papua, Indonesia. Clinical and laboratory data were linked for all patients presenting to...

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Bibliographic Details
Published in:PLoS medicine 2013-12, Vol.10 (12), p.e1001575; discussion e1001575
Main Authors: Douglas, Nicholas M, Lampah, Daniel A, Kenangalem, Enny, Simpson, Julie A, Poespoprodjo, Jeanne R, Sugiarto, Paulus, Anstey, Nicholas M, Price, Ric N
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anemia
Anemia - epidemiology
Anemia - etiology
Anemia - metabolism
Child
Child, Preschool
Erythrocytes
Female
Hemoglobins - metabolism
Humans
Indonesia
Infant
Infant, Newborn
Malaria
Malaria - complications
Malaria - epidemiology
Malaria - metabolism
Male
Medical research
Medicine
Medicine, Experimental
Middle Aged
Parasites
Physiological aspects
Plasmodium
Plasmodium falciparum
Plasmodium falciparum - pathogenicity
Plasmodium vivax - pathogenicity
Risk Factors
Womens health
Young Adult
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Summary:The burden of anemia attributable to non-falciparum malarias in regions with Plasmodium co-endemicity is poorly documented. We compared the hematological profile of patients with and without malaria in southern Papua, Indonesia. Clinical and laboratory data were linked for all patients presenting to a referral hospital between April 2004 and December 2012. Data were available on patient demographics, malaria diagnosis, hemoglobin concentration, and clinical outcome, but other potential causes of anemia could not be identified reliably. Of 922,120 patient episodes (837,989 as outpatients and 84,131 as inpatients), a total of 219,845 (23.8%) were associated with a hemoglobin measurement, of whom 67,696 (30.8%) had malaria. Patients with P. malariae infection had the lowest hemoglobin concentration (n = 1,608, mean = 8.93 [95% CI 8.81-9.06]), followed by those with mixed species infections (n = 8,645, mean = 9.22 [95% CI 9.16-9.28]), P. falciparum (n = 37,554, mean = 9.47 [95% CI 9.44-9.50]), and P. vivax (n = 19,858, mean = 9.53 [95% CI 9.49-9.57]); p-value for all comparisons
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1001575