Nontuberculous mycobacterial disease mortality in the United States, 1999-2010: a population-based comparative study

Environmental nontuberculous mycobacteria (NTM) are ubiquitous organisms with which humans commonly interact. The epidemiologic characteristics of NTM diseases including mortality rate and its associated factors remain largely unknown. In this study, we explored the geographical area of exposure and...

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Bibliographic Details
Published in:PloS one 2014-03, Vol.9 (3), p.e91879
Main Authors: Mirsaeidi, Mehdi, Machado, Roberto F, Garcia, Joe G N, Schraufnagel, Dean E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Analysis
Bacterial infections
Biology
Bronchiectasis
Chemotherapy
Child
Child, Preschool
Chronic obstructive lung disease
Chronic obstructive pulmonary disease
Comorbidity
Comparative studies
Critical care
Death
Demographic variables
Demographics
Disease control
Disease prevention
Diseases
Epidemiology
Ethnicity
Fatalities
Female
Health aspects
Hispanic people
Hispanics
HIV
Host-Pathogen Interactions
Humans
Infant
Infections
Lung diseases
Male
Medical laboratories
Medical research
Medicine
Middle Aged
Minority & ethnic groups
Mortality
Mycobacterium Infections, Nontuberculous - epidemiology
Mycobacterium Infections, Nontuberculous - ethnology
Mycobacterium Infections, Nontuberculous - microbiology
Mycobacterium Infections, Nontuberculous - mortality
Nontuberculous Mycobacteria - physiology
Obstructive lung disease
Population
Population studies
Population-based studies
Respiratory diseases
Rheumatoid arthritis
Smoking
Studies
Tobacco
Tuberculosis
United States - epidemiology
United States - ethnology
Urbanization
Young Adult
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Summary:Environmental nontuberculous mycobacteria (NTM) are ubiquitous organisms with which humans commonly interact. The epidemiologic characteristics of NTM diseases including mortality rate and its associated factors remain largely unknown. In this study, we explored the geographical area of exposure and mortality and comorbid conditions of affected persons to determine environment, host, and host-pathogen interactive factors. We analyzed mortality related to nontuberculous mycobacterial infections from 1999 through 2010 by examining multiple-cause-of-death data from the National Center for Health Statistics. Among those who died with these diseases, we analyzed age-adjusted mortality rates, trends, associations with demographic variables, and comorbid conditions and correlated this information with similar data for tuberculosis-related mortality during the same time. From 1999 through 2010, nontuberculous mycobacterial disease was reported as an immediate cause of death in 2,990 people in the United States with a combined overall mean age-adjusted mortality rate of 0.1 per 100,000 person-years. A significant increase in the number of NTM related deaths was seen from 1999 through 2010 (R(2) = 0.72, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0091879