Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations

Recent studies have used a variety of analytical methods to identify genes targeted by selection in high-altitude populations located throughout the Tibetan Plateau. Despite differences in analytic strategies and sample location, hypoxia-related genes, including EPAS1 and EGLN1, were identified in m...

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Bibliographic Details
Published in:PloS one 2014-03, Vol.9 (3), p.e88252-e88252
Main Authors: Wuren, Tana, Simonson, Tatum S, Qin, Ga, Xing, Jinchuan, Huff, Chad D, Witherspoon, David J, Jorde, Lynn B, Ge, Ri-Li
Format: Article
Language:English
Subjects:
Adaptation
Adaptation, Physiological - genetics
Adolescent
Adult
Aged
Alleles
Altitude
Analytical methods
Asian Continental Ancestry Group
Basic Helix-Loop-Helix Transcription Factors - genetics
Biology and Life Sciences
Blood pressure
DNA, Mitochondrial - genetics
Female
Genealogy
Genes
Genetics
Genome-Wide Association Study
Genomes
Genomics
Haplotypes
Heme Oxygenase (Decyclizing) - genetics
High altitude
High-altitude environments
Humans
Hypertension
Hypoxia
Hypoxia - ethnology
Hypoxia - genetics
Hypoxia-Inducible Factor-Proline Dioxygenases - genetics
Identification methods
Male
Mathematical analysis
Medicine
Middle Aged
Natural selection
Polymorphism, Single Nucleotide
Population
Population studies
Populations
Rivers
Selection, Genetic
Single-nucleotide polymorphism
Studies
Target recognition
Tibet
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Summary:Recent studies have used a variety of analytical methods to identify genes targeted by selection in high-altitude populations located throughout the Tibetan Plateau. Despite differences in analytic strategies and sample location, hypoxia-related genes, including EPAS1 and EGLN1, were identified in multiple studies. By applying the same analytic methods to genome-wide SNP information used in our previous study of a Tibetan population (n = 31) from the township of Maduo, located in the northeastern corner of the Qinghai-Tibetan Plateau (4200 m), we have identified common targets of natural selection in a second geographically and linguistically distinct Tibetan population (n = 46) in the Tuo Tuo River township (4500 m). Our analyses provide evidence for natural selection based on iHS and XP-EHH signals in both populations at the p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0088252