Polymorphisms of immunity genes and susceptibility to otitis media in children

• Published in: PloS one 2014-04, Vol.9 (4), p.e93930
• Main Authors: Nokso-Koivisto, Johanna, Chonmaitree, Tasnee, Jennings, Kristofer, Matalon, Reuben, Block, Stan, Patel, Janak A
• Format: Article
• Language: English
• Subjects: Adaptive immunity; Adaptive Immunity - genetics; Age; Alleles; Analysis; Biology and Life Sciences; Breastfeeding & lactation; Care and treatment; Chemokines; Child; Child, Preschool; Children; CX3C Chemokine Receptor 1; CX3CR1 protein; Cytokines; Data processing; Development and progression; Disease susceptibility; Ear diseases; Environmental factors; Female; Follow-Up Studies; Gene Frequency; Generalized linear models; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Genetics; Genotype; Health risks; Humans; Immunity; Immunity, Innate - genetics; Infant; Infections; Infectious diseases; Interleukin 10; Interleukin 5; Interleukin 8; Interleukins - genetics; Interleukins - physiology; Male; Medicine and Health Sciences; Otitis media; Otitis Media - epidemiology; Otitis Media - genetics; Otitis Media - immunology; Otolaryngology; Pediatrics; Polymorphism, Single Nucleotide; Prospective Studies; Receptors, Chemokine - genetics; Receptors, Chemokine - physiology; Respiratory syncytial virus; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - genetics; Respiratory Tract Infections - immunology; Retrospective Studies; Risk; Risk factors; Single-nucleotide polymorphism; Studies; Vaccines; Viral infections; Virus Diseases - genetics; Virus Diseases - immunology
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0093930

Acute otitis media (OM) is a common disease which often develops through complex interactions between the host, the pathogen and environmental factors. We studied single nucleotide polymorphisms (SNPs) of genes involved in innate and adaptive immunity, and other host and environmental factors for their role in OM. Using Sequenom Massarray platform, 21 SNPs were studied in 653 children from prospective (n = 202) and retrospective (n = 451) cohorts. Data were analyzed for the relationship between SNPs and upper respiratory infection (URI) frequency, risk of acute OM during URI episodes, and proneness to recurrent OM. Increased risk for OM proneness was associated with CX3CR1 (Thr280Met) SNP and with a jointly interactive group of IL-10 (-1082) SNP, IL-1β (-511) wild type genotype and white race. Family history of OM proneness independently increased the risk for frequent URIs, OM occurrence during URI, and OM proneness. Additionally, IL-1β (-31) SNP was associated with increased risk for frequent URIs, but IL-10 (-592), IL-1β (-511), IL-5 (-746) and IL-8 (-251) SNPs were associated with decreased risk of URI. IL-1β (-31), CX3CR1 (Thr280Met), IL-10 (-1082) and IL-1β (-511) SNPs were associated with increased risk for frequent URIs or OM proneness.