Serum iron concentration, but not hemoglobin, correlates with TIMI risk score and 6-month left ventricular performance after primary angioplasty for acute myocardial infarction

• Published in: PloS one 2014-08, Vol.9 (8), p.e104495-e104495
• Main Authors: Huang, Ching-Hui, Chang, Chia-Chu, Kuo, Chen-Ling, Huang, Ching-Shan, Chiu, Tzai-Wen, Lin, Chih-Sheng, Liu, Chin-San
• Format: Article
• Language: English
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - physiopathology; Acute Coronary Syndrome - surgery; Acute coronary syndromes; Adult; Aged; Anemia; Angioplasty; Angioplasty, Balloon, Coronary; Balloon angioplasty; Bioindicators; Biomarkers; Biomarkers - blood; Cardiac patients; Cardiology; Cytokines; Echocardiography; Electrocardiography; Female; Health aspects; Heart; Heart attack; Heart attacks; Heart failure; Heart Ventricles - physiopathology; Hemoglobin; Hemoglobins; Hemoglobins - metabolism; Hospitals; Humans; Inflammation; Interleukin 6; Internal medicine; Iron; Iron - blood; Iron deficiency; Iron deficiency anemia; Male; Medicine; Medicine and Health Sciences; Metabolism; Middle Aged; Mortality; Myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - physiopathology; Myocardial Infarction - surgery; Nutrient deficiency; Oxidative stress; Patients; Prognosis; Prospective Studies; Regression analysis; Risk; Risk factors; Stroke Volume; Studies; Thrombolysis; Trend analysis; Ventricle
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0104495

Anemia is associated with high mortality and poor prognosis after acute coronary syndrome (ACS). Increased red cell distribution width (RDW) is a strong independent predictor for adverse outcomes in ACS. The common underlying mechanism for anemia and increased RDW value is iron deficiency. It is not clear whether serum iron deficiency without anemia affects left ventricular (LV) performance after primary angioplasty for acute myocardial infarction (AMI). We investigated the prognostic value of serum iron concentration on LV ejection fraction (EF) at 6 months and its relationship to thrombolysis in myocardial infarction (TIMI) risk score in post MI patients. We recruited 55 patients who were scheduled to undergo primary coronary balloon angioplasty after AMI and 54 age- and sex-matched volunteers. Serum iron concentration and interleukin-6 levels were measured before primary angioplasty. LVEF was measured by echocardiography at baseline and after 6 months. TIMI risk score was calculated for risk stratification. Serum iron concentration was significantly lower in those in whom LVEF had not improved ≥ 10% from baseline (52.7 ± 24.1 versus 80.8 ± 50.8 µg/dl, P = 0.016) regardless of hemoglobin level, and was significantly lower in the AMI group than in the control group (62.5 ± 37.7 versus 103.0 ± 38.1 µg/dl, P