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An in vivo three-dimensional magnetic resonance imaging-based averaged brain collection of the neonatal piglet (Sus scrofa)
Due to the fact that morphology and perinatal growth of the piglet brain is similar to humans, use of the piglet as a translational animal model for neurodevelopmental studies is increasing. Magnetic resonance imaging (MRI) can be a powerful tool to study neurodevelopment in piglets, but many of the...
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Published in: | PloS one 2014-09, Vol.9 (9), p.e107650 |
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description | Due to the fact that morphology and perinatal growth of the piglet brain is similar to humans, use of the piglet as a translational animal model for neurodevelopmental studies is increasing. Magnetic resonance imaging (MRI) can be a powerful tool to study neurodevelopment in piglets, but many of the MRI resources have been produced for adult humans. Here, we present an average in vivo MRI-based atlas specific for the 4-week-old piglet. In addition, we have developed probabilistic tissue classification maps. These tools can be used with brain mapping software packages (e.g. SPM and FSL) to aid in voxel-based morphometry and image analysis techniques. The atlas enables efficient study of neurodevelopment in a highly tractable translational animal with brain growth and development similar to humans. |
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subjects | Aging Animal behavior Animals Animals, Newborn Biology and Life Sciences Brain Brain - cytology Brain - growth & development Brain mapping Brain Mapping - methods Female Hogs Image analysis Image processing Imaging, Three-Dimensional Magnetic resonance Magnetic Resonance Imaging Male Medical imaging Medicine and Health Sciences Morphometry Neonates Neurodevelopment Neuroimaging Newborn babies NMR Nuclear magnetic resonance Research and Analysis Methods Resonance Software Software packages Sus scrofa Swine Translation |
title | An in vivo three-dimensional magnetic resonance imaging-based averaged brain collection of the neonatal piglet (Sus scrofa) |
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