An elevated peripheral blood lymphocyte-to-monocyte ratio predicts favorable response and prognosis in locally advanced breast cancer following neoadjuvant chemotherapy

Neoadjuvant chemotherapy (NCT) is a standard treatment option for locally advanced breast cancer. However, the lack of an efficient method to predict treatment response and patient prognosis hampers the clinical evaluation of patient eligibility for NCT. An elevated lymphocyte-to-monocyte ratio (LMR...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2014-11, Vol.9 (11), p.e111886-e111886
Main Authors: Ni, Xiao-Jian, Zhang, Xiao-Lan, Ou-Yang, Qian-Wen, Qian, Guo-Wei, Wang, Lei, Chen, Sheng, Jiang, Yi-Zhou, Zuo, Wen-Jia, Wu, Jiong, Hu, Xin, Shao, Zhi-Ming
Format: Article
Language:English
Subjects:
Adjuvant chemotherapy
Adult
Aged
Analysis
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Blood
Breast cancer
Breast Neoplasms - blood
Breast Neoplasms - drug therapy
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer
Cancer therapies
Cell number
Chemotherapy
Engineering and Technology
Family medical history
Female
Humans
Laboratories
Leukocyte Count
Lymphocytes
Lymphoma
Mammography
Medical prognosis
Medicine and Health Sciences
Middle Aged
Monocytes
Multivariate analysis
Nasopharyngeal carcinoma
Neoadjuvant Therapy
Neoplasm Grading
Neoplasm Staging
Neutrophils
Oncology
Patients
Peripheral blood
Prognosis
Radiation therapy
Research and Analysis Methods
ROC Curve
Surgery
Tumors
Ultrasonic imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neoadjuvant chemotherapy (NCT) is a standard treatment option for locally advanced breast cancer. However, the lack of an efficient method to predict treatment response and patient prognosis hampers the clinical evaluation of patient eligibility for NCT. An elevated lymphocyte-to-monocyte ratio (LMR) has been reported to be associated with a favorable prognosis for certain hematologic malignancies and for nasopharyngeal carcinoma; however, this association has not been investigated in breast cancer. The purpose of this study was to evaluate whether pre-NCT LMR analysis could predict the prognosis of patients with locally advanced breast cancer. A retrospective cohort of 542 locally advanced breast cancer patients (T3/T4 and/or N2/N3 disease) receiving NCT followed by radical surgery was recruited between May 2002 and August 2011 at the Fudan University Shanghai Cancer Center. Counts for pre-NCT peripheral absolute lymphocytes and monocytes were obtained and used to calculate the LMR. Univariate and multivariate analysis revealed that higher LMR levels (≥4.25) were significantly associated with favorable DFS (P = 0.009 and P = 0.011, respectively). Additionally, univariate analysis revealed that a higher lymphocyte count (≥1.5×109/L) showed borderline significance for improved DFS (P = 0.054), while a lower monocyte count (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0111886