MR angiography follow-up 10 years after cryptogenic nonperimesencephalic subarachnoid hemorrhage

• Published in: PloS one 2015-02, Vol.10 (2), p.e0117925-e0117925
• Main Authors: Wenz, Holger, Ehrlich, Gregory, Wenz, Ralf, Al Mahdi, Mohamad-Motaz, Scharf, Johann, Groden, Christoph, Schmiedek, Peter, Seiz-Rosenhagen, Marcel
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Aneurysm; Aneurysms; Angiography; Angiography, Digital Subtraction; Bleeding; Brain - diagnostic imaging; Child; Child, Preschool; Computed tomography; Data bases; Demographics; Demography; Digital imaging; Female; Follow-Up Studies; Hemorrhage; Humans; Ischemia; Lesions; Magnetic resonance; Magnetic Resonance Angiography; Magnetic resonance imaging; Male; Medical imaging; Middle Aged; Neurosurgery; NMR; Nuclear magnetic resonance; Patients; Risk factors; Siderosis; Stroke; Subarachnoid hemorrhage; Subarachnoid Hemorrhage - diagnosis; Treatment Outcome; Vasoconstriction; Vasospasm, Intracranial - diagnosis; Ventricle; Work stations; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0117925

Long-term magnetic resonance angiography (MRA) follow-up studies regarding cryptogenic nonperimesencephalic subarachnoid hemorrhage (nSAH) are scarce. This single-centre study identified all patients with angiographically verified cryptogenic nSAH from 1998 to 2007: The two main objectives were to prospectively assess the incidence of de novo aneurysm with 3.0-MRI years after cryptogenic nSAH in patients without evidence for further hemorrhage, and retrospectively assess patient demographics and outcome. From prospectively maintained report databases all patients with angiographically verified cryptogenic nSAH were identified. 21 of 29 patients received high-resolution 3T-MRI including time-of-flight and contrast-enhanced angiography, 10.2 ± 2.8 years after cryptogenic nSAH. MRA follow-up imaging was compared with initial digital subtraction angiography (DSA) and CT/MRA. Post-hemorrhage images were related to current MRI with reference to persistent lesions resulting from delayed cerebral ischemia (DCI) and post-hemorrhagic siderosis. Patient-based objectives were retrospectively abstracted from clinical databases. 29 patients were identified with cryptogenic nSAH, 17 (59%) were male. Mean age at time of hemorrhage was 52.9 ± 14.4 years (range 4 - 74 years). 21 persons were available for long-term follow-up. In these, there were 213.5 person years of MRI-follow-up. No de novo aneurysm was detected. Mean modified Rankin Scale (mRS) during discharge was 1.28. Post-hemorrhage radiographic vasospasm was found in three patients (10.3%); DCI-related lesions occurred in one patient (3.4%). Five patients (17.2%) needed temporary external ventricular drainage; long-term CSF shunt dependency was necessary only in one patient (3.4%). Initial DSA retrospectively showed a 2 x 2 mm aneurysm of the right distal ICA in one patient, which remained stable. Post-hemorrhage siderosis was detected 8.1 years after the initial bleeding in one patient (4.8%). Patients with cryptogenic nSAH have favourable outcomes and do not exhibit higher risks for de novo aneurysms. Therefore the need for long-term follow up after cryptogenic nSAH is questionable.