Fetal calcifications are associated with chromosomal abnormalities

The biological importance of calcifications occasionally noted in fetal tissues (mainly liver) at autopsy or ultrasound is largely unexplored. Previous reports hint at an association to infection, circulatory compromise, malformations or chromosomal abnormalities. To identify factors associated with...

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Bibliographic Details
Published in:PloS one 2015-04, Vol.10 (4), p.e0123343-e0123343
Main Authors: Sahlin, Ellika, Sirotkina, Meeli, Marnerides, Andreas, Iwarsson, Erik, Papadogiannakis, Nikos
Format: Article
Language:English
Subjects:
Abnormalities
Abortion
Archives & records
Autopsies
Autopsy
Bacterial infections
Calcification
Calcinosis - complications
Calcinosis - genetics
Case-Control Studies
Chromosome Aberrations
Chromosome Disorders - complications
Chromosome Disorders - genetics
Chromosomes
Chromosomes, Human, Pair 18 - genetics
Cytomegalovirus
Down Syndrome - complications
Down Syndrome - genetics
Female
Fetal Diseases - genetics
Fetuses
Fluorescence
Gestational Age
Health aspects
Humans
Infection
Infections
Intestine
Karyotype
Liver
Medicin och hälsovetenskap
Medicine
Monosomy
Pathology
Placenta
Polymerase chain reaction
Pregnancy
Retrospective Studies
Stillbirth
Studies
Tissues
Trisomy
Trisomy - genetics
Turner Syndrome - complications
Turner Syndrome - genetics
Ultrasound
Viral infections
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Summary:The biological importance of calcifications occasionally noted in fetal tissues (mainly liver) at autopsy or ultrasound is largely unexplored. Previous reports hint at an association to infection, circulatory compromise, malformations or chromosomal abnormalities. To identify factors associated with calcifications, we have performed a case-control study on the largest cohort of fetuses with calcifications described thus far. One-hundred and fifty-one fetuses with calcifications and 302 matched controls were selected from the archives of the Department of Pathology, Karolinska University Hospital. Chromosome analysis by karyotyping or quantitative fluorescence-polymerase chain reaction was performed. Autopsy and placenta reports were scrutinized for presence of malformations and signs of infection. Calcifications were mainly located in the liver, but also in heart, bowel, and other tissues. Fetuses with calcifications showed a significantly higher proportion of chromosomal abnormalities than controls; 50% vs. 20% (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0123343