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International Differences in Treatment and Clinical Outcomes for High Grade Glioma
High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in patients who receive specific treatments between cohorts...
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Published in: | PloS one 2015-06, Vol.10 (6), p.e0129602 |
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creator | Chien, Li-Nien Ostrom, Quinn T Gittleman, Haley Lin, Jia-Wei Sloan, Andrew E Barnett, Gene H Elder, J Bradley McPherson, Christopher Warnick, Ronald Chiang, Yung-Hsiao Lin, Chieh-Min Rogers, Lisa R Chiou, Hung-Yi Barnholtz-Sloan, Jill S |
description | High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in patients who receive specific treatments between cohorts in Ohio and Taiwan.
Patients aged 18 years and older at age of diagnosis with World Health Organization (WHO) grade III or IV astrocytoma from 2007-2012 were selected from the Ohio Brain Tumor Study and the Taiwan Cancer Registry. The treatment information was derived from medical chart reviews in Ohio and National Health Insurance Research Data in Taiwan. Treatment examined included surgical procedure (brain biopsy and/or resection), radiotherapy (radiation and/or radiosurgery), and alkylating chemotherapy. Kaplan-Meier and parametric survival models were used to examine the effect of treatment on survival, adjusted for age, sex, and comorbidities.
294 patients in Ohio and 1,097 patients in Taiwan met the inclusion criteria. 70.3% patients in Ohio and 51.4% in Taiwan received surgical resection, followed by concurrent chemoradiation. Patients who received this treatment had the highest survival rate, with a 1-year survival rate of 72.8% in Ohio and 73.4% in Taiwan. Patients who did not receive surgical resection, followed by concurrent chemoradiation had an increased risk of death (hazard ratio of 5.03 [95% confidence interval (CI): 3.61-7.02] in Ohio and 1.49 [95% CI: 1.31-1.71] in Taiwan) after adjustment for age, sex, and comorbidities.
Surgical resection followed by concurrent chemoradiation was associated with higher survival rate of patients with high grade glioma in both Ohio and Taiwan; however, one-third of patients in Ohio and half in Taiwan did not receive this treatment. |
doi_str_mv | 10.1371/journal.pone.0129602 |
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Patients aged 18 years and older at age of diagnosis with World Health Organization (WHO) grade III or IV astrocytoma from 2007-2012 were selected from the Ohio Brain Tumor Study and the Taiwan Cancer Registry. The treatment information was derived from medical chart reviews in Ohio and National Health Insurance Research Data in Taiwan. Treatment examined included surgical procedure (brain biopsy and/or resection), radiotherapy (radiation and/or radiosurgery), and alkylating chemotherapy. Kaplan-Meier and parametric survival models were used to examine the effect of treatment on survival, adjusted for age, sex, and comorbidities.
294 patients in Ohio and 1,097 patients in Taiwan met the inclusion criteria. 70.3% patients in Ohio and 51.4% in Taiwan received surgical resection, followed by concurrent chemoradiation. Patients who received this treatment had the highest survival rate, with a 1-year survival rate of 72.8% in Ohio and 73.4% in Taiwan. Patients who did not receive surgical resection, followed by concurrent chemoradiation had an increased risk of death (hazard ratio of 5.03 [95% confidence interval (CI): 3.61-7.02] in Ohio and 1.49 [95% CI: 1.31-1.71] in Taiwan) after adjustment for age, sex, and comorbidities.
Surgical resection followed by concurrent chemoradiation was associated with higher survival rate of patients with high grade glioma in both Ohio and Taiwan; however, one-third of patients in Ohio and half in Taiwan did not receive this treatment.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0129602</identifier><identifier>PMID: 26061037</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age ; Aged ; Alkylation ; Astrocytoma ; Biopsy ; Brain ; Brain cancer ; Brain Neoplasms - epidemiology ; Brain Neoplasms - ethnology ; Brain Neoplasms - therapy ; Brain research ; Brain tumors ; Breast cancer ; Cancer therapies ; Care and treatment ; Chemoradiotherapy ; Chemotherapy ; Clinical outcomes ; Comorbidity ; Confidence intervals ; Deoxyribonucleic acid ; DNA ; Female ; Glioma ; Glioma - epidemiology ; Glioma - ethnology ; Glioma - therapy ; Gliomas ; Hospitals ; Humans ; Male ; Medical diagnosis ; Medical prognosis ; Medical research ; Medicine ; Middle Aged ; Morbidity ; National health insurance ; Neurosurgery ; Ohio ; Oncology ; Patient outcomes ; Patients ; Population ; Public health ; Radiation ; Radiation therapy ; Radiology ; Radiosurgery ; Sex ; Surgery ; Survival ; Survival Analysis ; Taiwan ; Treatment Outcome ; Tumors</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0129602</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Chien et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Chien et al 2015 Chien et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a57f73669fef9e787db8897b9c09fd2f847bc1f98ff45cd9808369168070891a3</citedby><cites>FETCH-LOGICAL-c692t-a57f73669fef9e787db8897b9c09fd2f847bc1f98ff45cd9808369168070891a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1687366623/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1687366623?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26061037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Castro, Maria G</contributor><creatorcontrib>Chien, Li-Nien</creatorcontrib><creatorcontrib>Ostrom, Quinn T</creatorcontrib><creatorcontrib>Gittleman, Haley</creatorcontrib><creatorcontrib>Lin, Jia-Wei</creatorcontrib><creatorcontrib>Sloan, Andrew E</creatorcontrib><creatorcontrib>Barnett, Gene H</creatorcontrib><creatorcontrib>Elder, J Bradley</creatorcontrib><creatorcontrib>McPherson, Christopher</creatorcontrib><creatorcontrib>Warnick, Ronald</creatorcontrib><creatorcontrib>Chiang, Yung-Hsiao</creatorcontrib><creatorcontrib>Lin, Chieh-Min</creatorcontrib><creatorcontrib>Rogers, Lisa R</creatorcontrib><creatorcontrib>Chiou, Hung-Yi</creatorcontrib><creatorcontrib>Barnholtz-Sloan, Jill S</creatorcontrib><title>International Differences in Treatment and Clinical Outcomes for High Grade Glioma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in patients who receive specific treatments between cohorts in Ohio and Taiwan.
Patients aged 18 years and older at age of diagnosis with World Health Organization (WHO) grade III or IV astrocytoma from 2007-2012 were selected from the Ohio Brain Tumor Study and the Taiwan Cancer Registry. The treatment information was derived from medical chart reviews in Ohio and National Health Insurance Research Data in Taiwan. Treatment examined included surgical procedure (brain biopsy and/or resection), radiotherapy (radiation and/or radiosurgery), and alkylating chemotherapy. Kaplan-Meier and parametric survival models were used to examine the effect of treatment on survival, adjusted for age, sex, and comorbidities.
294 patients in Ohio and 1,097 patients in Taiwan met the inclusion criteria. 70.3% patients in Ohio and 51.4% in Taiwan received surgical resection, followed by concurrent chemoradiation. Patients who received this treatment had the highest survival rate, with a 1-year survival rate of 72.8% in Ohio and 73.4% in Taiwan. Patients who did not receive surgical resection, followed by concurrent chemoradiation had an increased risk of death (hazard ratio of 5.03 [95% confidence interval (CI): 3.61-7.02] in Ohio and 1.49 [95% CI: 1.31-1.71] in Taiwan) after adjustment for age, sex, and comorbidities.
Surgical resection followed by concurrent chemoradiation was associated with higher survival rate of patients with high grade glioma in both Ohio and Taiwan; however, one-third of patients in Ohio and half in Taiwan did not receive this treatment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Alkylation</subject><subject>Astrocytoma</subject><subject>Biopsy</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - epidemiology</subject><subject>Brain Neoplasms - ethnology</subject><subject>Brain Neoplasms - therapy</subject><subject>Brain research</subject><subject>Brain tumors</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Chemoradiotherapy</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Female</subject><subject>Glioma</subject><subject>Glioma - epidemiology</subject><subject>Glioma - ethnology</subject><subject>Glioma - therapy</subject><subject>Gliomas</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>National health insurance</subject><subject>Neurosurgery</subject><subject>Ohio</subject><subject>Oncology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Population</subject><subject>Public health</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Radiology</subject><subject>Radiosurgery</subject><subject>Sex</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival 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Chieh-Min</au><au>Rogers, Lisa R</au><au>Chiou, Hung-Yi</au><au>Barnholtz-Sloan, Jill S</au><au>Castro, Maria G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>International Differences in Treatment and Clinical Outcomes for High Grade Glioma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-10</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0129602</spage><pages>e0129602-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in patients who receive specific treatments between cohorts in Ohio and Taiwan.
Patients aged 18 years and older at age of diagnosis with World Health Organization (WHO) grade III or IV astrocytoma from 2007-2012 were selected from the Ohio Brain Tumor Study and the Taiwan Cancer Registry. The treatment information was derived from medical chart reviews in Ohio and National Health Insurance Research Data in Taiwan. Treatment examined included surgical procedure (brain biopsy and/or resection), radiotherapy (radiation and/or radiosurgery), and alkylating chemotherapy. Kaplan-Meier and parametric survival models were used to examine the effect of treatment on survival, adjusted for age, sex, and comorbidities.
294 patients in Ohio and 1,097 patients in Taiwan met the inclusion criteria. 70.3% patients in Ohio and 51.4% in Taiwan received surgical resection, followed by concurrent chemoradiation. Patients who received this treatment had the highest survival rate, with a 1-year survival rate of 72.8% in Ohio and 73.4% in Taiwan. Patients who did not receive surgical resection, followed by concurrent chemoradiation had an increased risk of death (hazard ratio of 5.03 [95% confidence interval (CI): 3.61-7.02] in Ohio and 1.49 [95% CI: 1.31-1.71] in Taiwan) after adjustment for age, sex, and comorbidities.
Surgical resection followed by concurrent chemoradiation was associated with higher survival rate of patients with high grade glioma in both Ohio and Taiwan; however, one-third of patients in Ohio and half in Taiwan did not receive this treatment.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26061037</pmid><doi>10.1371/journal.pone.0129602</doi><oa>free_for_read</oa></addata></record> |
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identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2015-06, Vol.10 (6), p.e0129602 |
issn | 1932-6203 1932-6203 |
language | eng |
recordid | cdi_plos_journals_1687366623 |
source | Publicly Available Content (ProQuest); PubMed Central |
subjects | Adolescent Adult Age Aged Alkylation Astrocytoma Biopsy Brain Brain cancer Brain Neoplasms - epidemiology Brain Neoplasms - ethnology Brain Neoplasms - therapy Brain research Brain tumors Breast cancer Cancer therapies Care and treatment Chemoradiotherapy Chemotherapy Clinical outcomes Comorbidity Confidence intervals Deoxyribonucleic acid DNA Female Glioma Glioma - epidemiology Glioma - ethnology Glioma - therapy Gliomas Hospitals Humans Male Medical diagnosis Medical prognosis Medical research Medicine Middle Aged Morbidity National health insurance Neurosurgery Ohio Oncology Patient outcomes Patients Population Public health Radiation Radiation therapy Radiology Radiosurgery Sex Surgery Survival Survival Analysis Taiwan Treatment Outcome Tumors |
title | International Differences in Treatment and Clinical Outcomes for High Grade Glioma |
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