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International Differences in Treatment and Clinical Outcomes for High Grade Glioma

High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in patients who receive specific treatments between cohorts...

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Published in:PloS one 2015-06, Vol.10 (6), p.e0129602
Main Authors: Chien, Li-Nien, Ostrom, Quinn T, Gittleman, Haley, Lin, Jia-Wei, Sloan, Andrew E, Barnett, Gene H, Elder, J Bradley, McPherson, Christopher, Warnick, Ronald, Chiang, Yung-Hsiao, Lin, Chieh-Min, Rogers, Lisa R, Chiou, Hung-Yi, Barnholtz-Sloan, Jill S
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cited_by cdi_FETCH-LOGICAL-c692t-a57f73669fef9e787db8897b9c09fd2f847bc1f98ff45cd9808369168070891a3
cites cdi_FETCH-LOGICAL-c692t-a57f73669fef9e787db8897b9c09fd2f847bc1f98ff45cd9808369168070891a3
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container_title PloS one
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creator Chien, Li-Nien
Ostrom, Quinn T
Gittleman, Haley
Lin, Jia-Wei
Sloan, Andrew E
Barnett, Gene H
Elder, J Bradley
McPherson, Christopher
Warnick, Ronald
Chiang, Yung-Hsiao
Lin, Chieh-Min
Rogers, Lisa R
Chiou, Hung-Yi
Barnholtz-Sloan, Jill S
description High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in patients who receive specific treatments between cohorts in Ohio and Taiwan. Patients aged 18 years and older at age of diagnosis with World Health Organization (WHO) grade III or IV astrocytoma from 2007-2012 were selected from the Ohio Brain Tumor Study and the Taiwan Cancer Registry. The treatment information was derived from medical chart reviews in Ohio and National Health Insurance Research Data in Taiwan. Treatment examined included surgical procedure (brain biopsy and/or resection), radiotherapy (radiation and/or radiosurgery), and alkylating chemotherapy. Kaplan-Meier and parametric survival models were used to examine the effect of treatment on survival, adjusted for age, sex, and comorbidities. 294 patients in Ohio and 1,097 patients in Taiwan met the inclusion criteria. 70.3% patients in Ohio and 51.4% in Taiwan received surgical resection, followed by concurrent chemoradiation. Patients who received this treatment had the highest survival rate, with a 1-year survival rate of 72.8% in Ohio and 73.4% in Taiwan. Patients who did not receive surgical resection, followed by concurrent chemoradiation had an increased risk of death (hazard ratio of 5.03 [95% confidence interval (CI): 3.61-7.02] in Ohio and 1.49 [95% CI: 1.31-1.71] in Taiwan) after adjustment for age, sex, and comorbidities. Surgical resection followed by concurrent chemoradiation was associated with higher survival rate of patients with high grade glioma in both Ohio and Taiwan; however, one-third of patients in Ohio and half in Taiwan did not receive this treatment.
doi_str_mv 10.1371/journal.pone.0129602
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Ronald</au><au>Chiang, Yung-Hsiao</au><au>Lin, Chieh-Min</au><au>Rogers, Lisa R</au><au>Chiou, Hung-Yi</au><au>Barnholtz-Sloan, Jill S</au><au>Castro, Maria G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>International Differences in Treatment and Clinical Outcomes for High Grade Glioma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-10</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0129602</spage><pages>e0129602-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to compare the treatment patterns of high grade glioma to examine survival patterns in patients who receive specific treatments between cohorts in Ohio and Taiwan. Patients aged 18 years and older at age of diagnosis with World Health Organization (WHO) grade III or IV astrocytoma from 2007-2012 were selected from the Ohio Brain Tumor Study and the Taiwan Cancer Registry. The treatment information was derived from medical chart reviews in Ohio and National Health Insurance Research Data in Taiwan. Treatment examined included surgical procedure (brain biopsy and/or resection), radiotherapy (radiation and/or radiosurgery), and alkylating chemotherapy. Kaplan-Meier and parametric survival models were used to examine the effect of treatment on survival, adjusted for age, sex, and comorbidities. 294 patients in Ohio and 1,097 patients in Taiwan met the inclusion criteria. 70.3% patients in Ohio and 51.4% in Taiwan received surgical resection, followed by concurrent chemoradiation. Patients who received this treatment had the highest survival rate, with a 1-year survival rate of 72.8% in Ohio and 73.4% in Taiwan. Patients who did not receive surgical resection, followed by concurrent chemoradiation had an increased risk of death (hazard ratio of 5.03 [95% confidence interval (CI): 3.61-7.02] in Ohio and 1.49 [95% CI: 1.31-1.71] in Taiwan) after adjustment for age, sex, and comorbidities. Surgical resection followed by concurrent chemoradiation was associated with higher survival rate of patients with high grade glioma in both Ohio and Taiwan; however, one-third of patients in Ohio and half in Taiwan did not receive this treatment.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26061037</pmid><doi>10.1371/journal.pone.0129602</doi><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
ispartof PloS one, 2015-06, Vol.10 (6), p.e0129602
issn 1932-6203
1932-6203
language eng
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source Publicly Available Content (ProQuest); PubMed Central
subjects Adolescent
Adult
Age
Aged
Alkylation
Astrocytoma
Biopsy
Brain
Brain cancer
Brain Neoplasms - epidemiology
Brain Neoplasms - ethnology
Brain Neoplasms - therapy
Brain research
Brain tumors
Breast cancer
Cancer therapies
Care and treatment
Chemoradiotherapy
Chemotherapy
Clinical outcomes
Comorbidity
Confidence intervals
Deoxyribonucleic acid
DNA
Female
Glioma
Glioma - epidemiology
Glioma - ethnology
Glioma - therapy
Gliomas
Hospitals
Humans
Male
Medical diagnosis
Medical prognosis
Medical research
Medicine
Middle Aged
Morbidity
National health insurance
Neurosurgery
Ohio
Oncology
Patient outcomes
Patients
Population
Public health
Radiation
Radiation therapy
Radiology
Radiosurgery
Sex
Surgery
Survival
Survival Analysis
Taiwan
Treatment Outcome
Tumors
title International Differences in Treatment and Clinical Outcomes for High Grade Glioma
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