Glycemic Control and Mortality in Diabetic Patients Undergoing Dialysis Focusing on the Effects of Age and Dialysis Type: A Prospective Cohort Study in Korea

Active glycemic control has been proven to delay the onset and slow the progression of diabetic retinopathy, nephropathy, and neuropathy in diabetic patients, but the optimal level is obscure in end-stage renal disease. In this study, we evaluated the effect of hemoglobin A1c (HbA1c) on mortality of...

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Bibliographic Details
Published in:PloS one 2015-08, Vol.10 (8), p.e0136085-e0136085
Main Authors: Park, Ji In, Bae, Eunjin, Kim, Yong-Lim, Kang, Shin-Wook, Yang, Chul Woo, Kim, Nam-Ho, Lee, Jung Pyo, Kim, Dong Ki, Joo, Kwon Wook, Kim, Yon Su, Lee, Hajeong
Format: Article
Language:English
Subjects:
Active control
Adolescent
Adult
Age
Age Factors
Aged
Analysis
Blood Glucose - analysis
Body mass
Body mass index
Body size
Chronic kidney failure
Cohort analysis
Comorbidity
Confidence intervals
Development and progression
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetes therapy
Diabetic neuropathy
Diabetic retinopathy
Diabetics
Dialysis
End-stage renal disease
Enrollments
Fatalities
Female
Glucose
Glycated Hemoglobin A - analysis
Hemodialysis
Hemoglobin
Hemoglobins
Humans
Hyperglycemia - etiology
Hyperglycemia - mortality
Hypoglycemia - etiology
Hypoglycemia - mortality
Infections
Internal medicine
Kidney diseases
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - mortality
Kidney Failure, Chronic - therapy
Male
Medicine
Middle Aged
Mortality
Movement disorders
Nephropathy
Neuropathy
Observational studies
Older people
Patient outcomes
Patients
Peritoneal dialysis
Peritoneal Dialysis - mortality
Peritoneum
Prospective Studies
Quality of Life
Renal Dialysis - mortality
Republic of Korea
Retinopathy
Studies
Subgroups
Survival
Survival Rate
Young Adult
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Description
Summary:Active glycemic control has been proven to delay the onset and slow the progression of diabetic retinopathy, nephropathy, and neuropathy in diabetic patients, but the optimal level is obscure in end-stage renal disease. In this study, we evaluated the effect of hemoglobin A1c (HbA1c) on mortality of diabetic patients on dialysis, focusing on age and dialysis type. Of 3,302 patients enrolled in the prospective cohort for end-stage renal disease in Korea between August 2008 and October 2013, 1,239 diabetic patients who had been diagnosed with diabetes or having HbA1c≥6.5% at the time of enrollment were analyzed. Age was categorized as
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0136085