Excessive Weight Gain during the First Year of Peritoneal Dialysis Is Associated with Inflammation, Diabetes Mellitus, and a Rapid Decrease in Residual Renal Function

Significant weight gain is a potential problem in most patients starting peritoneal dialysis (PD); however, few studies have explored the clinical effects of increased body weight (BW) in these patients. We evaluated the effect of excess weight gain during the first year after PD on residual renal f...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2015-09, Vol.10 (9), p.e0139033-e0139033
Main Authors: Kim, Jwa-Kyung, Kim, Young-Su, Song, Young Rim, Kim, Hyung Jik, Kim, Sung Gyun, Moon, Sung Jin
Format: Article
Language:English
Subjects:
Analysis
Blood pressure
Body composition
Body fat
Body mass index
Body weight
Body weight gain
Care and treatment
Confidence intervals
Development and progression
Diabetes
Diabetes mellitus
Diabetes Mellitus - physiopathology
Dialysis
Epidemiology
Female
Health aspects
Hospitals
Humans
Inflammation
Inflammation - complications
Inflammation - physiopathology
Internal medicine
Kidney - physiopathology
Kidney diseases
Kidney Function Tests
Linear Models
Male
Medical prognosis
Medicine
Middle Aged
Mortality
Multivariate Analysis
Obesity
Patient outcomes
Patients
Peritoneal dialysis
Peritoneal Dialysis - adverse effects
Peritoneum
Proteins
Proteinuria
Renal function
Risk Factors
Studies
Time measurement
Urine
Weight Gain
Weight gain measurement
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Significant weight gain is a potential problem in most patients starting peritoneal dialysis (PD); however, few studies have explored the clinical effects of increased body weight (BW) in these patients. We evaluated the effect of excess weight gain during the first year after PD on residual renal function (RRF). A total of 148 incident PD patients were analyzed in a longitudinal observational study. The mean duration of follow-up was 23.8 months. RRF was measured at baseline (within 1 month of starting PD) and thereafter at 6-month intervals for 2-3 years or until loss of RRF. BW was measured at the time of RRF measurement, and excess weight gain was defined as a BW increase over the median value (3.0%). The median 1-year increase in BW was 2.3kg (IQR, 1.01-4.58) or 3.0% (IQR, 1.13-5.31). The mean slope of RRF decline was -0.068 ± 0.053 mL/min/month/1.73m2, and RRF loss developed in 48 patients at a mean follow-up time of 19.4 ± 6.8 months. Patients with BW increases > 3.0% showed significantly increased RRF decline rate compared to those without excess weight gain (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0139033