A Significant Increase in the Incidence of Central Precocious Puberty among Korean Girls from 2004 to 2010

Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children. Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the records of 21,351 children...

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Bibliographic Details
Published in:PloS one 2015-11, Vol.10 (11), p.e0141844-e0141844
Main Authors: Kim, Shin Hye, Huh, Kyoung, Won, Sungho, Lee, Kuk-Wha, Park, Mi-Jung
Format: Article
Language:English
Subjects:
Age
Analogs
Asian Continental Ancestry Group
Child
Children
Children & youth
Cohort analysis
Endocrinology
Female
Gender
Girls
Gonadotropin-releasing hormone
Gonadotropin-Releasing Hormone - metabolism
Gonadotropins
Health insurance
Hospitals
Humans
Incidence
Insurance claims
Korea - epidemiology
Male
Medical diagnosis
Medicine
Pediatrics
Physical growth
Pituitary (anterior)
Population
Population studies
Prevalence
Puberty
Puberty, Precocious - epidemiology
Public health
Reviews
Teenagers
Trends
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Summary:Few studies have explored the trends in central precocious puberty (CPP) in Asian populations. This study assessed the prevalence and annual incidence of CPP among Korean children. Using data from the Korean Health Insurance Review Agency from 2004 to 2010, we reviewed the records of 21,351 children, including those registered with a diagnosis of CPP for the first time and those diagnosed with CPP who were treated with gonadotropin-releasing hormone analogs. The prevalence of CPP was 55.9 per 100,000 girls and 1.7 per 100,000 boys, respectively. The overall incidence of CPP was 15.3 per 100,000 girls, and 0.6 per 100,000 boys. The annual incidence of CPP in girls significantly increased from 3.3 to 50.4 per 100,000 girls; whereas in boys, it gradually increased from 0.3 to 1.2 per 100,000 boys. The annual incidence of CPP in girls consistently increased at all ages year by year, with greater increases at older ages (≥6 years of age), and smaller increases in girls aged < 6 years. In contrast, the annual incidence remained relatively constant in boys aged < 8 years, while a small increase was observed only in boys aged 8 years. The increase of annual incidence showed significant differences depending on age and gender (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0141844